Observational studyPloS one2015
High prevalence of nickel allergy in an overweight female population: a pilot observational analysis.
Observational study in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Systemic Nickel Allergy Syndrome.American journal of medicine open · 2026Review
- Systemic Nickel Allergy Syndrome: A Critical Appraisal of an Unvalidated Diagnostic Entity.Clinical and translational allergy · 2026Review
- Nickel-resistant gut microbiota: a missing link between environmental exposure and metabolic disease.Frontiers in microbiology · 2026Article
- Development of a Whole-Cell System Based on the Use of Genetically Modified Protoplasts to Detect Nickel Ions in Food Matrices.International journal of molecular sciences · 2024Article
- Differential Effects of Obesity, Hyperlipidaemia, Dietary Intake and Physical Inactivity on Type I versus Type IV Allergies.Nutrients · 2022Article
- Conjunctional Relationship between Serum Uric Acid and Serum Nickel with Non-Alcoholic Fatty Liver Disease in Men: A Cross-Sectional Study.International journal of environmental research and public health · 2022Article
- Development, Optimization, Characterization, and Application of Electrochemical Biosensors for Detecting Nickel Ions in Food.Biosensors · 2021Article
- Diet Intervention Study through Telemedicine Assistance for Systemic Nickel Allergy Syndrome Patients during the COVID-19 Pandemic.Nutrients · 2021Article
- Nickel Sensitivity Is Associated with GH-IGF1 Axis Impairment and Pituitary Abnormalities on MRI in Overweight and Obese Subjects.International journal of molecular sciences · 2020Article
- Environmental heavy metals and cardiovascular diseases: Status and future direction.Chronic diseases and translational medicine · 2020Review
- Update of the risk assessment of nickel in food and drinking water.EFSA journal. European Food Safety Authority · 2020Article
- Generalised urticaria following ingestion of a nickel-plated coin in a 4-year-old girl.BMJ case reports · 2020Article
- Article
- Mid-upper arm circumference as a simple tool for identifying central obesity and insulin resistance in type 2 diabetes.PloS one · 2020Article
- Prevalence of contact allergy to metals in the European general population with a focus on nickel and piercings: The EDEN Fragrance Study.Contact dermatitis · 2018Article
- Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals.PloS one · 2018Article
- Heavy metal contamination of prenatal vitamins.Toxicology reports · 2018Article
- Nickel-resistant bacteria isolated in human microbiome.New microbes and new infections · 2017Article
- Prevalence of Self-reported Allergic Diseases and IgE Levels: A 2010 KNHANES Analysis.Allergy, asthma & immunology research · 2017Article
- Impact of nickel oral hyposensitization on quality of life in systemic nickel allergy syndrome.International journal of immunopathology and pharmacologyObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextIn our Allergy Unit, we incidentally observed that a low Nickel diet, prescribed for delayed allergy to Nickel sulfate, reduced body mass index (BMI) and waist circumference in overweight patients.
objectivesThis pilot cross-sectional analysis was undertaken to compare the prevalence of Nickel allergy of overweight individuals versus the general population. We also had the chance to report the efficacy of a low Nickel diet on BMI and waist circumference in Nickel-sensitive overweight subjects.
methodsEighty-seven overweight subjects, with a BMI > 26 Kg/m2, were consecutively enrolled in a health prevention program, and screened for the presence of Nickel allergy. The enrolled population was mostly females (72/87) (82.8%). Forty-three overweight women and two men showed a Nickel allergy and started a low Nickel diet. After 6-months of dieting, 24 overweight allergic women could be traced and changes in BMI and waist circumference were calculated. MAIN OUTCOME MEASUREMENTS: Prevalence of Nickel allergy in overweight.
resultsPrevalence of Nickel allergy in overweight female was 59.7%, compared with a prevalence rate of 12.5% in the general population. A significant reduction in BMI was observed in 24 out of 43 overweight females with Nickel allergy after 24 weeks of a low Nickel diet. Relative to baseline, mean BMI decrease was 4.2 ± 0.5 (P < 0.001) and the mean decline in waist circumference was 11.7 ± 0.6 cm (P < 0.001).
conclusionsThis pilot observational analysis showed a substantially higher prevalence of Nickel allergy among overweight females, especially those with metabolic syndrome and fatty liver disease. A normocaloric low Nickel diet was effective in reducing BMI in this population. Further research is strongly needed to confirm these preliminary findings.
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