Evidence map›Paper›PMID 25822927›Full record

ArticleJournal of the American Society for Mass Spectrometry2015

Mass Spectrometry Imaging and GC-MS Profiling of the Mammalian Peripheral Sensory-Motor Circuit.

Stanislav S Rubakhin, Alexander Ulanov, Jonathan V Sweedler

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins.Chemphyschem : a European journal of chemical physics and physical chemistry · 2018
    Article
  4. Peptidomics and Secretomics of the Mammalian Peripheral Sensory-Motor System.Journal of the American Society for Mass Spectrometry · 2015
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Stanislav S RubakhinDepartment of Chemistry, University of Illinois at Urbana-Champaign and the Beckman Institute for Advanced Science and Technology, Urbana, IL, 61801, USA.
Alexander Ulanov
Jonathan V Sweedler

Funding

The UIUC Neuroproteomics Center on Cell-Cell SignalingP30DA018310 · NIDA · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI SANDRA L RODRIGUEZ ZAS · 2004 to 2026
$24.9M
Glia classification via single cell metabolomicsR21MH100704 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RUBAKHIN, STANISLAV S., SWEEDLER, JONATHAN V. · 2013 to 2014
$419k
THE INTERNAL ORGANIZATION OF INFERIOR TEMPORAL CORTEXF31MH010070 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI STEELE, GREGORY E · 1991 to 1992
–
NIDA NIH HHS P30 DA018310NIDA NIH HHS P30DA018310NIMH NIH HHS R21 MH100704NIMH NIH HHS R21 MH100704A
6 · The paper itself

Abstract

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) has evolved to become an effective discovery tool in science and clinical diagnostics. Here, chemical imaging approaches are applied to well-defined regions of the mammalian peripheral sensory-motor system, including the dorsal root ganglia (DRG) and adjacent nerves. By combining several MSI approaches, analyte coverage is increased and 195 distinct molecular features are observed. Principal component analysis suggests three chemically different regions within the sensory-motor system, with the DRG and adjacent nerve regions being the most distinct. Investigation of these regions using gas chromatography-mass spectrometry corroborate these findings and reveal important metabolic markers related to the observed differences. The heterogeneity of the structurally, physiologically, and functionally connected regions demonstrates the intricate chemical and spatial regulation of their chemical composition.

Indexed as

AnimalsFemaleGanglia, SpinalGas Chromatography-Mass SpectrometryMalePrincipal Component AnalysisRats, Long-EvansSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Identifiers

PMID25822927
PMCPMC4425624

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.