Evidence map›Paper›PMID 25822926›Full record

ReviewBioconjugate chemistry2015

Guiding principles in the design of molecular bioconjugates for vaccine applications.

Haipeng Liu, Darrell J Irvine

Abstract readReview
In one paragraph

Review in Bioconjugate chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Synthetic organic materials for targeting immunotherapies to lymph nodes.Chemistry of materials : a publication of the American Chemical Society · 2024
    Article
  6. Article
  7. Molecular DNA dendron vaccines.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Calix[Journal of advanced research · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Biodegradable PLGA-Vaccines · 2020
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Haipeng Liu†Department of Chemical Engineering and Materials Science, Wayne State University, Detroit, Michigan 48202, United States.
Darrell J Irvine▼Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, United States.

Funding

Vaccine Adjuvant/ Delivery Systems CoreP01AI104715 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI ALLEN, TODD M · 2013 to 2017
$12.3M
Structural Approches to HIV-1 Immunogen Design for BNAb GenerationU19AI091693 · NIAID · DANA-FARBER CANCER INST · PI REINHERZ, ELLIS L · 2010 to 2015
$9.9M
Engineered lipid vesicles as potent vaccine vectors for HIVR01AI095109 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI IRVINE, DARRELL J · 2011 to 2015
$1.6M
Design Molecular Vaccines for Type 1 DiabetesR56DK103651 · NIDDK · WAYNE STATE UNIVERSITY · PI LIU, HAIPENG · 2014 to 2015
$476k
Howard Hughes Medical InstituteNIAID NIH HHS AI091693NIAID NIH HHS AI095109NIAID NIH HHS AI104715NIAID NIH HHS P01 AI104715NIAID NIH HHS R01 AI095109NIAID NIH HHS U19 AI091693NIDDK NIH HHS R56 DK103651NIDDK NIH HHS R56DK103651
6 · The paper itself

Abstract

Antigen- and adjuvant-based bioconjugates that can stimulate the immune system play an important role in vaccine applications. Bioconjugates have demonstrated unique physicochemical and biological properties, enabling vaccines to be delivered to key immune cells, to target specific intracellular pathways, or to mimic immunogenic properties of natural pathogens. In this Review we highlight recent advances in such molecular immunomodulators, with an emphasis on the structure-function relationships that provide the foundation for rational design of safe and effective vaccines and immunotherapies.

Indexed as

Drug DesignAnimalsAntigen PresentationAntigen-Presenting CellsHumansLymphatic SystemVaccinesVaccines

Identifiers

PMID25822926
PMCPMC4694040

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.