ArticlePloS one2015
Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Mitochonic acid 5 increases boar sperm quality by mitigating mitochondrial dysfunction.Frontiers in cell and developmental biology · 2025Article
- Pyrroloquinoline quinone ameliorates PM2.5-induced pulmonary fibrosis through targeting epithelial-mesenchymal transition.Journal of cellular and molecular medicine · 2024Article
- Cellular stress in the pathogenesis of nonalcoholic steatohepatitis and liver fibrosis.Nature reviews. Gastroenterology & hepatology · 2023Review
- PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice.Frontiers in endocrinology · 2022Article
- The Power of Plasticity-Metabolic Regulation of Hepatic Stellate Cells.Cell metabolism · 2021Review
- Developmental Programming of NAFLD by Parental Obesity.Hepatology communications · 2020Review
- Nanocarrier-mediated antioxidant delivery for liver diseases.Theranostics · 2020Review
- Apoptotic effects of hsian-tsao (Food science & nutrition · 2019Article
- Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice.Hepatology communications · 2018Article
- Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice.Molecules (Basel, Switzerland) · 2017Article
- Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing.International journal of molecular medicine · 2017Article
- The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts.Frontiers in physiology · 2016Review
- Role of NADPH oxidases in the redox biology of liver fibrosis.Redox biology · 2015Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injuries, and its progression toward cirrhosis is the major cause of liver-related morbidity and mortality worldwide. However, anti-fibrotic treatment remains an unconquered area for drug development. Accumulating evidence indicate that oxidative stress plays a critical role in liver fibrogenesis. In this study, we found that PQQ, a natural anti-oxidant present in a wide variety of human foods, exerted potent anti-fibrotic and ROS-scavenging activity in Balb/C mouse models of liver fibrosis. The antioxidant activity of PQQ was involved in the modulation of multiple steps during liver fibrogenesis, including chronic liver injury, hepatic inflammation, as well as activation of hepatic stellate cells and production of extracellular matrix. PQQ also suppressed the up-regulation of RACK1 in activated HSCs in vivo and in vitro. Our data suggest that PQQ suppresses oxidative stress and liver fibrogenesis in mice, and provide rationale for the clinical application of PQQ in the prevention and treatment of liver fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.