ArticleNature materials2015
Memoryless self-reinforcing directionality in endosomal active transport within living cells.
Article in Nature materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Anomalous Dynamics of Superparamagnetic Colloidal Microrobots with Tailored Statistics.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Thermodynamic uncertainty relation for systems with active Ornstein-Uhlenbeck particles.PNAS nexus · 2025Article
- Stick-slip motion and universal statistics of cargo transport within living cells.bioRxiv : the preprint server for biology · 2025Article
- Heterogeneous model for superdiffusive movement of dense core vesicles in C. elegans.Scientific reports · 2025Article
- Article
- Real-Time Tracking of Vesicles in Living Cells Reveals That Tau-Hyperphosphorylation Suppresses Unidirectional Transport by Motor Proteins.Chemical & biomedical imaging · 2024Article
- Diffusion in Porous Rock Is Anomalous.Environmental science & technology · 2024Article
- Statistical modeling of mRNP transport in dendrites: A comparative analysis of β-actin and Arc mRNP dynamics.Traffic (Copenhagen, Denmark) · 2023Article
- Burst of hopping trafficking correlated reversible dynamic interactions between lipid droplets and mitochondria under starvation.Exploration (Beijing, China) · 2023Article
- Identification of nanoparticles as vesicular cargoNanoscale advances · 2023Article
- Ensemble heterogeneity mimics ageing for endosomal dynamics within eukaryotic cells.Scientific reports · 2023Article
- Plasmodium sporozoite search strategy to locate hotspots of blood vessel invasion.Nature communications · 2023Article
- Population heterogeneity in the fractional master equation, ensemble self-reinforcement, and strong memory effects.Physical review. E · 2023Article
- Exponential increase of transition rates in metastable systems driven by non-Gaussian noise.Scientific reports · 2023Article
- A machine learning approach to discover migration modes and transition dynamics of heterogeneous dendritic cells.Frontiers in immunology · 2023Article
- Two GPSes in a Ball: Deciphering the Endosomal Tug-of-War Using Plasmonic Dark-Field STORM.JACS Au · 2022Article
- Article
- Lévy Walk Dynamics in an External Constant Force Field in Non-Static Media.Journal of statistical physics · 2022Article
- Glass-like characteristics of intracellular motion in human cells.Biophysical journal · 2021Article
- How Useful can the Voigt Profile be in Protein Folding Processes?The protein journal · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to Brownian transport, the active motility of microbes, cells, animals and even humans often follows another random process known as truncated Lévy walk. These stochastic motions are characterized by clustered small steps and intermittent longer jumps that often extend towards the size of the entire system. As there are repeated suggestions, although disagreement, that Lévy walks have functional advantages over Brownian motion in random searching and transport kinetics, their intentional engineering into active materials could be useful. Here, we show experimentally in the classic active matter system of intracellular trafficking that Brownian-like steps self-organize into truncated Lévy walks through an apparent time-independent positive feedback such that directional persistence increases with the distance travelled persistently. A molecular model that allows the maximum output of the active propelling forces to fluctuate slowly fits the experiments quantitatively. Our findings offer design principles for programming efficient transport in active materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.