ArticlePloS one2015
Antipyretic therapy in critically ill patients with sepsis: an interaction with body temperature.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Guideline for Medication Management of Distressing Symptoms in Older Patients Receiving End-of-Life Palliative Care.Journal of evidence-based medicine · 2026Guideline
- Long-term health effects of antipyretic drug use in the aging population: a systematic review.Journal of medicine and life · 2024Pooled it
- Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses.BMJ (Clinical research ed.) · 2022Pooled it
- Antipyretic Therapy in Critically Ill Septic Patients: A Systematic Review and Meta-Analysis.Critical care medicine · 2017Pooled it
- The cycle of infectious fever - how it affects bacterial infections.Frontiers in cellular and infection microbiology · 2026Review
- Fever in Sepsis Revisited: Is a Little Heat What We Need?Open forum infectious diseases · 2025Review
- The Effect of Body Temperature Changes on the Course of Treatment in Patients With Pneumonia and Sepsis: Results of an Observational Study.Interactive journal of medical research · 2024Article
- Hypofibrinogenemia is an independent predictor of hemophagocytic lymphohistiocytosis in children with sepsis.Scientific reports · 2023Article
- Study of thermo-regulation as a worsening marker of experimental sepsis in an animal model.Revista latino-americana de enfermagem · 2020Article
- Sepsis-Induced Myocardial Dysfunction (SIMD): the Pathophysiological Mechanisms and Therapeutic Strategies Targeting Mitochondria.Inflammation · 2020Review
- High 28-day mortality in critically ill patients with sepsis and concomitant active cancer.The Journal of international medical research · 2018Article
- Hotspot Analysis of Sepsis Literature.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- High Serum Iron level is Associated with Increased Mortality in Patients with Sepsis.Scientific reports · 2018Article
- [Antipyretics in intensive care patients].Der Anaesthesist · 2017Review
- Targeted temperature management in neurological intensive care unit.World journal of methodology · 2017Review
- Effect of Antipyretic Therapy on Mortality in Critically Ill Patients with Sepsis Receiving Mechanical Ventilation Treatment.Canadian respiratory journal · 2017Article
- Quadratic function between arterial partial oxygen pressure and mortality risk in sepsis patients: an interaction with simplified acute physiology score.Scientific reports · 2016Article
- Naïve Bayes classification in R.Annals of translational medicine · 2016Article
- Acetaminophen in critically ill patients, a therapy in search for big data analytics.Journal of thoracic disease · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveThe effect of antipyretic therapy on mortality in patients with sepsis remains undetermined. The present study aimed to investigate the role of antipyretic therapy in ICU patients with sepsis by using a large clinical database.
methodsThe multiparameter intelligent monitoring in intensive care II (MIMIC- II) database was employed for the study. Adult patients with sepsis were included for analysis. Antipyretic therapy included antipyretic medication and external cooling. Multivariable model with interaction terms were employed to explore the association of antipyretic therapy and mortality risk. MAIN
resultsA total of 15,268 patients fulfilled inclusion criteria and were included in the study. In multivariable model by treating temperature as a continuous variable, there was significant interaction between antipyretic therapy and the maximum temperature (Tmax). While antipyretic therapy had no significant effect on mortality in low temperature quintiles, antipyretic therapy was associated with increased risk of death in the quintile with body temperature >39°C (OR: 1.29, 95% CI: 1.04-1.61).
conclusionOur study shows that there is no beneficial effect on reducing mortality risk with the use of antipyretic therapy in ICU patients with sepsis. External cooling may even be harmful in patients with sepsis.
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