ArticleThe Journal of investigative dermatology2015
Interferon-Gamma Enhances TLR3 Expression and Anti-Viral Activity in Keratinocytes.
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 52 citations in OpenAlex.
- Article
- Article
- RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes.Scientific reports · 2025Article
- JAK Signaling Is Critically Important in Cytokine-Induced Viral Susceptibility of Keratinocytes.International journal of molecular sciences · 2023Article
- Bakuchiol and Ethyl (Linoleate/Oleate) Synergistically Modulate Endocannabinoid Tone in Keratinocytes and Repress Inflammatory Pathway mRNAs.JID innovations : skin science from molecules to population health · 2023Article
- "Input/output cytokines" in epidermal keratinocytes and the involvement in inflammatory skin diseases.Frontiers in immunology · 2023Review
- The host transcriptome change involved in the inhibitory effect of exogenous interferon-γ on Getah virus replication.Frontiers in microbiology · 2023Article
- The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa.Inflammation · 2022Article
- Bioactive substances in the stratum corneum of the epidermis found as indicators of skin damage due to sun exposure.Photodermatology, photoimmunology & photomedicine · 2022Article
- The interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation.The Journal of biological chemistry · 2022Review
- Cytokines and chemokines: The vital role they play in herpes simplex virus mucosal immunology.Frontiers in immunology · 2022Review
- The network interplay of interferon and Toll-like receptor signaling pathways in the anti-Candida immune response.Scientific reports · 2021Article
- Lower peripheral blood Toll-like receptor 3 expression is associated with an unfavorable outcome in severe COVID-19 patients.Scientific reports · 2021Article
- Molecular Mechanisms of ZC3H12C/Reg-3 Biological Activity and Its Involvement in Psoriasis Pathology.International journal of molecular sciences · 2021Article
- Extracellular vesicles produced by primary human keratinocytes in response to TLR agonists induce stimulus-specific responses in antigen-presenting cells.Cellular signalling · 2021Article
- Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps.Allergy · 2021Article
- Weighted gene coexpression network and experimental analyses identify lncRNA SPRR2C as a regulator of the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis.Cell death & disease · 2021Article
- C3a and Its Receptor C3aR Are Detectable in Normal Human Epidermal Keratinocytes and Are Differentially Regulated via TLR3 and LL37.Journal of innate immunity · 2021Article
- Pathogenic TLR3 Variant in a Patient with Recurrent Herpes Simplex Virus 1-Triggered Erythema Multiforme.Journal of clinical immunology · 2021Article
- Skin Immunity and Tolerance: Focus on Epidermal Keratinocytes Expressing HLA-G.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toll-like receptors (TLRs) recognize specific microbial products in the innate immune response. TLR3, a double-stranded RNA sensor, is thought to have an important role in viral infections, but the regulation of TLR3 expression and its function in keratinocytes are not fully understood. Here we show the Th1 cytokine IFN-γ increased the TLR3 expression via STAT1 in cultured normal human epidermal keratinocytes (NHEKs). Co-stimulation with IFN-γ and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-β, IL-6, IL-8, and human β-defensin-2 in NHEKs compared with poly (I:C) or IFN-γ alone. These synergistic inductions were significantly inhibited by an endosomal acidification inhibitor, chloroquine, and by TLR3 siRNA. Co-stimulation with IFN-γ and poly (I:C) also significantly enhanced the anti-viral activity against herpes simplex virus type-1 in NHEKs compared with poly (I:C) or IFN-γ alone. In addition to the in vitro findings, an immunohistochemical analysis revealed IFN-γ-positive cells surrounding herpetic vesicles. These findings indicate that IFN-γ might contribute to the innate immune response to cutaneous viral infections by enhancing TLR3 expression and function in keratinocytes.
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