ArticlePLoS genetics2015
Inhibition of telomere recombination by inactivation of KEOPS subunit Cgi121 promotes cell longevity.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Epigenetic pharmacology in aging: from mechanisms to therapies for age-related disorders.Frontiers in pharmacology · 2025Review
- Article
- Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions ineLife · 2024Article
- Dynamics of CD44Scientific reports · 2024Article
- Article
- Conservation and Diversification of tRNA tInternational journal of molecular sciences · 2022Review
- The structural and functional workings of KEOPS.Nucleic acids research · 2021Review
- Smc5/6 in the rDNA modulates lifespan independently of Fob1.Aging cell · 2021Article
- Reciprocal hemizygosity analysis reveals that the Saccharomyces cerevisiae CGI121 gene affects lag time duration in synthetic grape must.G3 (Bethesda, Md.) · 2021Article
- Identification of TP53RK-Binding Protein (TPRKB) Dependency inMolecular cancer research : MCR · 2019Article
- KEOPS complex promotes homologous recombination via DNA resection.Nucleic acids research · 2019Article
- Review
- Transcriptome-wide Analysis of Roles for tRNA Modifications in Translational Regulation.Molecular cell · 2017Article
- Telomere recombination pathways: tales of several unhappy marriages.Current genetics · 2017Review
- Rad6-Bre1-mediated H2B ubiquitination regulates telomere replication by promoting telomere-end resection.Nucleic acids research · 2017Article
- Tethering telomerase to telomeres increases genome instability and promotes chronological aging in yeast.Aging · 2016Article
- Multiple Rad52-Mediated Homology-Directed Repair Mechanisms Are Required to Prevent Telomere Attrition-Induced Senescence in Saccharomyces cerevisiae.PLoS genetics · 2016Article
- Correction: Inhibition of Telomere Recombination by Inactivation of KEOPS Subunit Cgi121 Promotes Cell Longevity.PLoS genetics · 2015Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA double strand break (DSB) is one of the major damages that cause genome instability and cellular aging. The homologous recombination (HR)-mediated repair of DSBs plays an essential role in assurance of genome stability and cell longevity. Telomeres resemble DSBs and are competent for HR. Here we show that in budding yeast Saccharomyces cerevisiae telomere recombination elicits genome instability and accelerates cellular aging. Inactivation of KEOPS subunit Cgi121 specifically inhibits telomere recombination, and significantly extends cell longevity in both telomerase-positive and pre-senescing telomerase-negative cells. Deletion of CGI121 in the short-lived yku80(tel) mutant restores lifespan to cgi121Δ level, supporting the function of Cgi121 in telomeric single-stranded DNA generation and thus in promotion of telomere recombination. Strikingly, inhibition of telomere recombination is able to further slow down the aging process in long-lived fob1Δ cells, in which rDNA recombination is restrained. Our study indicates that HR activity at telomeres interferes with telomerase to pose a negative impact on cellular longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.