ArticleScientific reports2015
Lactobacillus rhamnosus lowers zebrafish lipid content by changing gut microbiota and host transcription of genes involved in lipid metabolism.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 1 of them a synthesis that pooled it.
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Who cites it
82 citing papers in PubMed, 1 synthesis or guideline pooled it, 242 citations in OpenAlex.
- A systematic review of advances in intestinal microflora of fish.Fish physiology and biochemistry · 2021Pooled it
- Gut-Microbial Responses to Acute Polyester Microplastic Exposure in Zebrafish: Dysbiosis, Opportunistic Bacteria, and Functional Impact.International journal of molecular sciences · 2026Article
- Dietary Cerium (Ammonium Ceric Nitrate) Promoted the Growth, Intestinal Digestive Enzyme Activity, and Positive Modulation of Intestinal Microbiota of Largemouth Bass (Animals : an open access journal from MDPI · 2026Article
- Energy efficiency and neural control of continuous versus intermittent swimming in a fishlike robot.Science robotics · 2026Article
- Metagenomic profiling of fish-associated microbiota: ecological perspectives from freshwater to marine environment-a review.Archives of microbiology · 2026Review
- Regulatory Effects of a Lipid-Lowering StrainAquaculture nutrition · 2026Article
- Dose-dependent effects of dietary quercetin on cecal microbiota, hematological responses, and production efficiency in Arbor Acres broiler chickens.Veterinary world · 2026Article
- Impact of dietary composition on behavioural expression and gut microbiome dynamics in zebrafish.Pflugers Archiv : European journal of physiology · 2025Article
- Gut microbiota composition combined with reduced intestinal fatty acid uptake prevents hepatic steatosis in obesity-resistant mice fed a high-fat diet.Scientific reports · 2025Article
- Bacillus velezensis FiA2 as an Oxydifficidin-Producing Strain and its Effects on the Growth Performance, Immunity, Intestinal Microbiota, and Resistance to Aeromonas salmonicida Infection in Carassius carassius.Probiotics and antimicrobial proteins · 2025Article
- Research Progress on the Mechanism of Action and Screening Methods of Probiotics for Lowering Blood Lipid Levels.Foods (Basel, Switzerland) · 2025Review
- Effect of DietaryInternational journal of molecular sciences · 2025Article
- Impacts of Black Soldier Fly (Animals : an open access journal from MDPI · 2024Article
- Diverse mechanisms by which chemical pollutant exposure alters gut microbiota metabolism and inflammation.Environment international · 2024Review
- Comparative Analysis of Physiological Responses and Intestinal Microbiota in Juvenile Soft-Shelled Turtle (Animals : an open access journal from MDPI · 2024Article
- Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease.Cell death discovery · 2024Review
- Effect of fatty acid-enriched black soldier fly larvae meal combined with chitinase on the metabolic processes of Nile tilapia.The British journal of nutrition · 2024Article
- Bacterial networks in Atlantic salmon with Piscirickettsiosis.Scientific reports · 2023Article
- Exposure to Roundup and Antibiotics Alters Gut Microbial Communities, Growth, and Behavior inBiology · 2023Article
- Ginkgo biloba extract alleviates fatty liver hemorrhagic syndrome in laying hens via reshaping gut microbiota.Journal of animal science and biotechnology · 2023Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The microbiome plays an important role in lipid metabolism but how the introduction of probiotic communities affects host lipid metabolism is poorly understood. Using a multidisciplinary approach we addressed this knowledge gap using the zebrafish model by coupling high-throughput sequencing with biochemical, molecular and morphological analysis to evaluate the changes in the intestine. Analysis of bacterial 16S libraries revealed that Lactobacillus rhamnosus was able to modulate the gut microbiome of zebrafish larvae, elevating the abundance of Firmicutes sequences and reducing the abundance of Actinobacteria. The gut microbiome changes modulated host lipid processing by inducing transcriptional down-regulation of genes involved in cholesterol and triglycerides metabolism (fit2, agpat4, dgat2, mgll, hnf4α, scap, and cck) concomitantly decreasing total body cholesterol and triglyceride content and increasing fatty acid levels. L. rhamnosus treatment also increased microvilli and enterocyte lengths and decreased lipid droplet size in the intestinal epithelium. These changes resulted in elevated zebrafish larval growth. This integrated system investigation demonstrates probiotic modulation of the gut microbiome, highlights a novel gene network involved in lipid metabolism, provides an insight into how the microbiome regulates molecules involved in lipid metabolism, and reveals a new potential role for L. rhamnosus in the treatment of lipid disorders.
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