ArticleInternational journal of clinical pharmacy2015
Diagnostic evaluation and risk factors for drug allergies in children: from clinical history to skin and challenge tests.
Article in International journal of clinical pharmacy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Evaluation of pediatric patients with drug allergy confirmed by in vivo diagnostic tests.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Drug hypersensitivity reactions in children in clinical practice: A WAO Statement.The World Allergy Organization journal · 2025Review
- Evaluation of drug-related anaphylaxis in children: multi-center study.European journal of pediatrics · 2025Article
- Risk factors, clinical presentations, and common culprits in drug allergies: a case-control study from Türkiye.Postepy dermatologii i alergologii · 2025Article
- Risk factors for drug hypersensitivity reactions in children.Italian journal of pediatrics · 2024Review
- Approach for delabeling beta-lactam allergy in children.Frontiers in allergy · 2023Review
- Drug Allergy in Children: What is the Actual Frequency of Drug Allergies?Sisli Etfal Hastanesi tip bulteni · 2022Article
- Altered vaginal microbiome and relative co-abundance network in pregnant women with penicillin allergy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2020Article
- Antituberculosis Drug-Induced Fixed Drug Eruption: A Case Report.Drug safety - case reports · 2018Article
- Antibiotic Allergy in Pediatrics.Pediatrics · 2018Review
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Authors and funding
6 authors.
Funding
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Abstract
backgroundParent or self-reported drug allergy claims frequently overestimate the real incidence of hypersensitivity reactions. A detailed and algorithmic diagnostic evaluation of drug reactions may allow a proper diagnosis.
objectiveThe aim of this study was to determine the confirmation rates and risk factors for confirmed allergic drug reactions in children.
settingMersin University Hospital in Turkey.
methodThe study consisted of children between ages of 8 months and 18 years with the history of suspected drug allergy as reported by the clinician or the patients. Parents were interviewed by a clinician to complete questionnaires that included questions about demographic data and characteristics of index drug reaction. Immediate reactions (IRs) were assessed with immediate-reading skin prick (SPT) and intradermal tests (IDT). Nonimmediate reactions (NIRs) were assessed with SPT, both early and delayed reading of IDT and patch tests. In case of negative skin tests, drug provocation tests were performed. The possible risk factors for confirmed drug allergy in univariate analysis (p < 0.1) were entered into the multivariate logistic regression analysis to determine independent predictors.
main outcome measure(1) Confirmation rates of drug allergy (2) Risk factors related to confirmed drug allergy in children.
resultsWe evaluated a total of 180 suspected drug allergy reactions in 97 children, mainly to antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs) and anticonvulsants. Among all suspected allergic drug reactions, 97 (53.9 %) were immediate type and 83 (46.1 %) were non-immediate type. The average time interval between the reaction and allergologic work-up was 5 months. Drug allergy confirmation rates were 30.1 % for beta-lactams, 27.2 % for non-betalactams, 21.1 % for NSAIDs and 30 % for anticonvulsants. Eight of 54 confirmed NIRs showed positivity on immediate skin tests. Regulatory T cells, TGF-β and IL-10 levels were not different between groups with and without confirmed drug allergy. A strong family and personal history of drug allergy were found to be significantly related to the confirmed allergic drug reactions.
conclusionParent or self-reported drug allergy should be evaluated with a standardized diagnostic work-up before strict prohibitions are made. In addition, family and personal histories of drug allergy were significant risk factors related to allergic drug reactions in children.
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