ArticleInflammatory bowel diseases2015
Body fat composition assessment using analytic morphomics predicts infectious complications after bowel resection in Crohn's disease.
Article in Inflammatory bowel diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Risk Factors and Predictive Biomarkers for Postoperative Complications in Crohn's Disease Surgery: Systematic Review.International journal of molecular sciences · 2026Pooled it
- Computed tomography derived analytic morphomics as predictors of clinical outcomes in trauma: a systematic narrative review.Emergency radiology · 2026Pooled it
- Systematic Review: The Impact and Importance of Body Composition in Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2022Pooled it
- Systematic review and meta-analysis: association between obesity/overweight and surgical complications in IBD.International journal of colorectal disease · 2022Pooled it
- Outcomes of inflammatory bowel disease surgery in obese versus non-obese patients: a meta-analysis.Techniques in coloproctology · 2019Pooled it
- Computed tomography enterography-based deep learning radiomics models of intestinal lesions and perienteric fat for predicting Crohn's disease activity: a multicenter cohort study.Quantitative imaging in medicine and surgery · 2026Article
- Health-Related Physical Fitness in Patients With Inflammatory Bowel Disease vs Healthy Control Subjects.Inflammatory bowel diseases · 2025Article
- GLP-1R Agonists and Their Therapeutic Potential in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases, a Systematic Review of the Literature.Biomedicines · 2025Review
- MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn's disease.Insights into imaging · 2025Article
- Influencing factors and preventive measures of infectious complications after intestinal resection for Crohn's disease.World journal of gastrointestinal surgery · 2024Article
- Automated Identification of Postoperative Infections to Allow Prediction and Surveillance Based on Electronic Health Record Data: Scoping Review.JMIR medical informatics · 2024Article
- Impact of Obesity and Metabolic Syndrome on IBD Outcomes.Digestive diseases and sciences · 2024Review
- The Impact of Obesity on Inflammatory Bowel Disease.Biomedicines · 2023Review
- Article
- Obesity, a challenge in the management of inflammatory bowel diseases.Immunologic research · 2022Review
- Article
- Impact of Obesity on Inflammatory Bowel Disease.Current gastroenterology reports · 2022Review
- Visceral adiposity and inflammatory bowel disease.International journal of colorectal disease · 2021Review
- Influence of nutritional status in the postoperative period of patients with inflammatory bowel disease.World journal of gastrointestinal pharmacology and therapeutics · 2021Review
- Prevalence and associated factors of obesity in inflammatory bowel disease: A case-control study.World journal of gastroenterology · 2020Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDecisions between medical and surgical management of Crohn's disease (CD) incorporate risk assessments for potential complications of each therapy. Analytic morphomics is a novel method of image analysis providing quantifiable measurements of body tissue composition, characterizing body fat more comprehensively than body mass index alone. The aim of this study was to determine the risk factors associated with postoperative complications in CD, incorporating fat composition analysis using analytic morphomics.
methodsWe performed a retrospective review of adults undergoing bowel resection for CD between 2004 and 2011 at a single center. Computed tomography obtained within 30 days prior to surgery underwent morphomic analysis for fat characterization. Postoperative infectious complications were defined as the need for a postoperative abdominal drain, intravenous antibiotics, or reoperation within 30 days. Bivariate and multivariate analyses using logistic regression were used to generate a prediction model of infectious complications.
resultsA total of 269 subjects met selection criteria; 27% incurred postoperative infectious complications. Bivariate analysis showed hemoglobin, albumin, surgical urgency, high-dose prednisone use, and subcutaneous-to-visceral fat volume distribution as predictors of complications. Body mass index, anti-tumor necrosis factor alpha therapies, and immunomodulator use were not predictors of complication. Multivariate modeling demonstrated a c-statistic of 0.77 and a negative predictive value of 81.1% with surgical urgency (odds ratio = 2.78; 95% confidence interval, 1.46-6.02; P = 0.004), subcutaneous-to-visceral fat distribution (odds ratio = 2.01; 95% confidence interval, 1.20-3.19; P = 0.006), and hemoglobin (odds ratio = 0.69; 95% confidence interval, 0.55-0.85; P = 0.001) as predictors of infectious complication.
conclusionsFat subtype and distribution are predictive of postoperative infectious complications after bowel resection for CD. Analytic morphomics provides additional body composition detail not captured by body mass index.
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