Evidence map›Paper›PMID 25821909›Full record

ArticleNature neuroscience2015

Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity.

Daisuke Tsuboi, Keisuke Kuroda, Motoki Tanaka, Takashi Namba, Yukihiko Iizuka, Shinichiro Taya, Tomoyasu Shinoda, Takao Hikita, Shinsuke Muraoka, Michiro Iizuka and 7 more

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In one paragraph

Article in Nature neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Zebrafish as a model to investigate the CRH axis and interactions with DISC1.Current opinion in endocrine and metabolic research · 2022
    Review
  5. Mutations in DISC1 alter IPNeuronal signaling · 2021
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2019
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Daisuke Tsuboi1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] JST, CREST, Tokyo, Japan.
Keisuke Kuroda1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] JST, CREST, Tokyo, Japan.
Motoki TanakaDepartment of Physiology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
Takashi Namba1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] JST, CREST, Tokyo, Japan.
Yukihiko Iizuka1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] JST, CREST, Tokyo, Japan.
Shinichiro Taya1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] JST, CREST, Tokyo, Japan. [3] Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, Kodaira, Tokyo, Japan.
Tomoyasu Shinoda1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
Takao Hikita1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] Department of Developmental and Regenerative Biology, Graduate School of Medical Science, Nagoya City University, Nagoya, Aichi, Japan.
Shinsuke MuraokaDepartment of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
Michiro Iizuka1] JST, CREST, Tokyo, Japan. [2] Department of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Ai NimuraDepartment of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
Akira MizoguchiDepartment of Neural Regeneration and Cell Communication, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Nobuyuki ShiinaDepartment of Neuronal Cell Biology, Okazaki Institute for Integrative Bioscience and National Institute for Basic Biology, National Institutes of Natural Sciences, Okazaki, Aichi, Japan.
Masahiro SokabeDepartment of Physiology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.ORCID 0000000177910166
Hideyuki OkanoDepartment of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan.
Katsuhiko MikoshibaBrain Science Institute, RIKEN, Wako, Saitama, Japan.
Kozo Kaibuchi1] Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan. [2] JST, CREST, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disrupted-in-schizophrenia 1 (DISC1) is a susceptibility gene for major psychiatric disorders, including schizophrenia. DISC1 has been implicated in neurodevelopment in relation to scaffolding signal complexes. Here we used proteomic analysis to screen for DISC1 interactors and identified several RNA-binding proteins, such as hematopoietic zinc finger (HZF), that act as components of RNA-transporting granules. HZF participates in the mRNA localization of inositol-1,4,5-trisphosphate receptor type 1 (ITPR1), which plays a key role in synaptic plasticity. DISC1 colocalizes with HZF and ITPR1 mRNA in hippocampal dendrites and directly associates with neuronal mRNAs, including ITPR1 mRNA. The binding potential of DISC1 for ITPR1 mRNA is facilitated by HZF. Studies of Disc1-knockout mice have revealed that DISC1 regulates the dendritic transport of Itpr1 mRNA by directly interacting with its mRNA. The DISC1-mediated mRNA regulation is involved in synaptic plasticity. We show that DISC1 binds ITPR1 mRNA with HZF, thereby regulating its dendritic transport for synaptic plasticity.

Indexed as

3' Untranslated RegionsAnimalsBiological TransportCytoplasmic GranulesDendritesHippocampusHumansInositol 1,4,5-Trisphosphate ReceptorsMiceMice, Inbred C57BLNerve Tissue ProteinsNeuronal PlasticityProtein BindingProtein Interaction MappingProteinsRecombinant Fusion Proteins3' Untranslated RegionsDISC1 protein, humanDisc1 protein, mouseInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseNerve Tissue ProteinsProteinsRecombinant Fusion ProteinsRNA-Binding ProteinsRNA, MessengerZfp385 protein, mouse

Identifiers

PMID25821909

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.