ArticleCanadian family physician Medecin de famille canadien2015
Narcotic tapering in pregnancy using long-acting morphine: an 18-month prospective cohort study in northwestern Ontario.
Article in Canadian family physician Medecin de famille canadien, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Opioid Detoxification During Pregnancy: A Systematic Review.Obstetrics and gynecology · 2018Pooled it
- Opioid use disorder and medication for opioid use disorder among pregnant women with commercial insurance in the United States, 2016-2020.Drug and alcohol dependence · 2026Article
- Addiction in the family: Two Indigenous families overcoming barriers to opioid agonist therapy.Canadian family physician Medecin de famille canadien · 2022Article
- Treatment of Opioid Use Disorder in Pregnant Women via Telemedicine: A Nonrandomized Controlled Trial.JAMA network open · 2020Article
- Opioids affect the fetal brain: reframing the detoxification debate.American journal of obstetrics and gynecology · 2019Article
- Update of the Scientific Opinion on opium alkaloids in poppy seeds.EFSA journal. European Food Safety Authority · 2018Article
- Opioid use in pregnancy and parenting: An Indigenous-based, collaborative framework for Northwestern Ontario.Canadian journal of public health = Revue canadienne de sante publique · 2018Article
- First Nations hepatitis C virus infections: Six-year retrospective study of on-reserve rates of newly reported infections in northwestern Ontario.Canadian family physician Medecin de famille canadien · 2017Article
- Treatment of Prescription Opioid Use Disorder in Pregnant Women.The American journal of psychiatry · 2017Article
- Observational study of the safety of buprenorphine+naloxone in pregnancy in a rural and remote population.BMJ open · 2016Observational
- Rural, Pregnant, and Opioid Dependent: A Systematic Review.Substance abuse : research and treatment · 2016Review
- Treating Women Who Are Pregnant and Parenting for Opioid Use Disorder and the Concurrent Care of Their Infants and Children: Literature Review to Support National Guidance.Journal of addiction medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo document the management of and outcomes for patients receiving narcotic replacement and tapering with long-acting morphine preparations during pregnancy.
designA prospective cohort study over 18 months.
settingNorthwestern Ontario.
participantsAll 600 births at Meno Ya Win Health Centre in Sioux Lookout, Ont, from January 1, 2012, to June 30, 2013, including 166 narcotic-exposed pregnancies.
interventionNarcotic replacement and tapering of narcotic use with long-acting morphine preparations.
main outcome measuresPrenatal management of maternal narcotic use, incidence of neonatal abstinence syndrome, and other neonatal outcomes.
resultsThe incidence of neonatal abstinence syndrome fell significantly to 18.1% of pregnancies exposed to narcotics (from 29.5% in a previous 2010 study, P = .003) among patients using narcotic replacement and tapering with long-acting morphine preparations. Neonatal outcomes were otherwise equivalent to those of the nonexposed pregnancies.
conclusionIn many patients, long-acting morphine preparations can be safely used and tapered in pregnancy, with a subsequent decrease in observed neonatal withdrawal symptoms.
Indexed as
Identifiers
25821873PMC4325877W2156414575What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.