ArticleJournal of immunology research2015
Significance of circulating and crevicular matrix metalloproteinase-9 in rheumatoid arthritis-chronic periodontitis association.
Article in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- The Potential of Gingival Crevicular Fluid as a Tool for Molecular Diagnosis: A Systematic Review.BioMed research international · 2024Pooled it
- The JNJ0966 Significantly Reduces the Elevated Serum MMP-9 and Blood Pressure Observed in SHRs With Periodontitis.International dental journal · 2026Article
- Proteomic and glycosylation biomarkers in rheumatoid arthritis: advancing early diagnosis and precision therapy.Clinical proteomics · 2026Review
- Gingivo-Periodontal Alterations in Pediatric Leukemia: A Comparative Analysis of IL-1β, IL-6, IL-17α and TGF-β1 Levels in Gingival Crevicular Fluid and Plasma.Dentistry journal · 2025Article
- Epidemiology and pathogenesis of the link between rheumatoid arthritis and periodontitis.Journal of Zhejiang University. Science. B · 2025Review
- Changes in MMP-9, T-SOD and SIRT-1 levels after non-surgical periodontal treatment.BMC oral health · 2025Article
- Inflammatory Responses in Periodontitis with or Without Rheumatoid Arthritis Alter Salivary Metallothionein and Zinc.Biological trace element research · 2023Article
- MMP-13, VEGF, and Disease Activity in a Cohort of Rheumatoid Arthritis Patients.Diagnostics (Basel, Switzerland) · 2023Article
- Microbiota and Oral Cancer as A Complex and Dynamic Microenvironment: A Narrative Review from Etiology to Prognosis.International journal of molecular sciences · 2022Review
- Recent advances in enzyme-related biomaterials for arthritis treatment.Frontiers in chemistry · 2022Review
- Sulfonylureas for Treatment of Periodontitis-Diabetes Comorbidity-Related Complications: Killing Two Birds With One Stone.Frontiers in pharmacology · 2021Review
- JAK/STAT pathway in pathology of rheumatoid arthritis (Review).Experimental and therapeutic medicine · 2020Review
- New insights into IL-17/IL-23 signaling in ankylosing spondylitis (Review).Experimental and therapeutic medicine · 2020Review
- Article
- Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature.Oral diseases · 2019Review
- Assessment of Salivary Levels of RANKL and OPG in Aggressive versus Chronic Periodontitis.Journal of immunology research · 2019Article
- Article
- The Biological Efficacy of Natural Products against Acute and Chronic Inflammatory Diseases in the Oral Region.Medicines (Basel, Switzerland) · 2018Review
- Hepatitis C Infection and Periodontal Disease: Is there a Common Immunological Link?Journal of immunology research · 2018Review
- The case for periodontitis in the pathogenesis of rheumatoid arthritis.Nature reviews. Rheumatology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the recent years, statistically significant associations between rheumatoid arthritis (RA) and periodontal disease have been identified. Emerging as a chronic inflammatory joint disease, RA displays various features and pathogenetic events similar to chronic periodontitis (CP). The purpose of this study was to evaluate the utility of determining systemic and crevicular levels of metalloproteinase-9 (MMP-9) as potential biomarkers for association between RA and CP. A total of fifty-six patients were included in the study. The subjects were categorized into four groups as follows: healthy-control (n = 21), active RA (n = 16), CP (n = 14), and RA-CP association (n = 12). Assessment of serum and crevicular concentrations of total MMP-9 (active and pro-MMP-9) was based on ELISA technique. The results of this study showed statistically significant differences of serum MMP-9 between patients groups and control. Serum levels of MMP-9 were similar in RA and RA-CP associated patients. Gingival crevicular fluid (GCF) recorded increased MMP-9 levels in RA-CP association subjects as compared to CP. Considering that RA-CP association is characterized by a disregulation of the inflammatory response, MMP-9 may play a role in the pathogenesis of RA-CP association. MMP-9 is therefore a sensitive tool in the diagnosis and management of patients affected by this binomial association.
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Registered trials
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