ArticleBioMed research international2015
Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
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- Article
- Cadmium toxicity alleviation in rats using lactobacillus-fermented and unfermented opuntia ficus-indica L. juices.Toxicology reports · 2025Article
- Opuntia ficus-indica var. Jalpa (Nopal) Induces Different Cell Death Mechanisms in Colorectal Cancer Cells Depending on the Extraction Method Used.Applied biochemistry and biotechnology · 2025Article
- Identification, Quantification, and Antioxidant Evaluation of Phenolic Compounds from ColoredAntioxidants (Basel, Switzerland) · 2025Article
- Isorhamnetin: Reviewing Recent Developments in Anticancer Mechanisms and Nanoformulation-Driven Delivery.International journal of molecular sciences · 2025Review
- Shielding Human Adipocytes From Inflammation: The Protective Potential of Polyphenol-Rich Opuntia ficus-indica Cladode Extract.Molecular nutrition & food research · 2025Article
- Oxidative Stress Protection and Anti-Inflammatory Activity of Polyphenolic Fraction fromMolecules (Basel, Switzerland) · 2025Article
- Potential role of NSAIDs loaded nano-formulations to treat inflammatory diseases.Inflammopharmacology · 2025Review
- Elucidating the isorhamnetin-3-O-glucoside-iNOS interaction via molecular dynamics and Hirshfeld surface analyses.PloS one · 2025Article
- Insights into bioactive constituents of onion (Allium cepa L.) waste: a comparative metabolomics study enhanced by chemometric tools.BMC complementary medicine and therapies · 2024Article
- Anti-Obesity Effect of DifferentNutrients · 2024Article
- Skin health properties ofHeliyon · 2023Article
- Anti-Inflammatory Study and Phytochemical Characterization ofACS omega · 2023Article
- Review
- Polyphenol-Dietary Fiber Conjugates from Fruits and Vegetables: Nature and Biological Fate in a Food and Nutrition Perspective.Foods (Basel, Switzerland) · 2023Review
- Review
- Phenolic Compounds' Occurrence inMolecules (Basel, Switzerland) · 2022Review
- Chemical Components ofMolecules (Basel, Switzerland) · 2022Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Opuntia ficus-indica (OFI) has been widely used in Mexico as a food and for the treatment of different health disorders such as inflammation and skin aging. Its biological properties have been attributed to different phytochemicals such as the isorhamnetin glycosides which are the most abundant flavonoids. Moreover, these compounds are considered a chemotaxonomic characteristic of OFI species. The aim of this study was to evaluate the effect of OFI extract and its isorhamnetin glycosides on different inflammatory markers in vitro and in vivo. OFI extract was obtained by alkaline hydrolysis of OFI cladodes powder and pure compounds were obtained by preparative chromatography. Nitric oxide (NO), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-) α, and interleukin- (IL-) 6 production were measured. NO production was tested in lipopolysaccharide-stimulated RAW 264.7 cells while in vivo studies were carried on croton oil-induced ear edema model. OFI extract and diglycoside isorhamnetin-glucosyl-rhamnoside (IGR) at 125 ng/mL suppressed the NO production in vitro (73.5 ± 4.8% and 68.7 ± 5.0%, resp.) without affecting cell viability. Likewise, IGR inhibited the ear edema (77.4 ± 5.7%) equating the indomethacin effects (69.5 ± 5.3%). Both IGR and OFI extract significantly inhibited the COX-2, TNF-α, and IL-6 production. IGR seems to be a suitable natural compound for development of new anti-inflammatory ingredient.
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