Evidence map›Paper›PMID 25821793›Full record

SynthesisBioMed research international2015

Predictors of mortality for nursing home-acquired pneumonia: a systematic review.

Naveen Dhawan, Naushira Pandya, Michael Khalili, Manuel Bautista, Anurag Duggal, Jaya Bahl, Vineet Gupta

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04396522 (Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04396522 completednot on this mapstarted 2019, after this paper: background citation

Application of Serial Body Composition Change for Risk Prediction in Treating Patients With Severe Pneumonia

TypeobservationalSponsorChang Gung Memorial HospitalRan2019 to 2023Enrolled194ConditionsPneumoniaArmsnoninvasively Bio-electrical Impedance Analysis (BIA)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. The Winter Respiratory Viral Season During the COVID-19 Pandemic.Journal of the American Medical Directors Association · 2020
    Article
  7. Article
  8. Observational
  9. Observational
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Naveen DhawanNova Southeastern University Health Sciences Division, Fort Lauderdale, FL 33314, USA.ORCID 0000-0002-5431-2195
Naushira PandyaNova Southeastern University Health Sciences Division, Fort Lauderdale, FL 33314, USA.
Michael KhaliliThe Commonwealth Medical College, Scranton, PA 18509, USA.
Manuel BautistaDivision of Pulmonary Medicine, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, USA.
Anurag DuggalDivision of Infectious Diseases, Medina Hospital (Cleveland Clinic), Medina, OH 44256, USA ; Division of Infectious Diseases, Northeast Ohio Medical University College of Medicine, Rootstown, OH 44272, USA.
Jaya BahlFlorida International University (FIU), North Miami Beach, FL 33181, USA.
Vineet GuptaDepartment of Medicine, University of California San Diego (UCSD), 200 West Arbor Drive, San Diego, CA 92103, USA.ORCID 0000-0003-4639-3316

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrent risk stratification tools, primarily used for CAP, are suboptimal in predicting nursing home acquired pneumonia (NHAP) outcome and mortality. We conducted a systematic review to evaluate current evidence on the usefulness of proposed predictors of NHAP mortality.

methodsPubMed (MEDLINE), EMBASE, and CINAHL databases were searched for articles published in English between January 1978 and January 2014. The literature search elicited a total of 666 references; 580 were excluded and 20 articles met the inclusion criteria for the final analysis.

resultsMore studies supported the Pneumonia Severity Index (PSI) as a superior predictor of NHAP severity. Fewer studies suggested CURB-65 and SOAR (especially for the need of ICU care) as useful predictors for NHAP mortality. There is weak evidence for biomarkers like C-reactive protein and copeptin as prognostic tools.

conclusionThe evidence supports the use of PSI as the best available indicator while CURB-65 may be an alternative prognostic indicator for NHAP mortality. Overall, due to the paucity of information, biomarkers may not be as effective in this role. Larger prospective studies are needed to establish the most effective predictor(s) or combination scheme to help clinicians in decision-making related to NHAP mortality.

Indexed as

AgedAged, 80 and overCross InfectionFemaleHomes for the AgedHumansIncidenceMaleNursing CareNursing HomesPneumonia, BacterialPrognosisRisk AssessmentSeverity of Illness IndexSurvival AnalysisTreatment Outcome

Identifiers

PMID25821793
PMCPMC4363502

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.