ArticleBeilstein journal of nanotechnology2015
Influence of gold, silver and gold-silver alloy nanoparticles on germ cell function and embryo development.
Article in Beilstein journal of nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 77 citations in OpenAlex.
- Achillea biebersteinii-Mediated Gold Nanoparticles on Oocyte Gene Expression and Follicular Development in Mice.International journal of molecular and cellular medicine · 2025Article
- Recent Advances in Synergistic Effect of Nanoparticles and Its Biomedical Application.International journal of molecular sciences · 2024Review
- Synthesis of green zinc-oxide nanoparticles and its dose-dependent beneficial effect on spermatozoa during preservation: sperm functional integrity, fertility and antimicrobial activity.Frontiers in bioengineering and biotechnology · 2024Article
- The Origin of the Intracellular Silver in Bacteria: A Comprehensive Study using Targeting Gold-Silver Alloy Nanoparticles.Advanced healthcare materials · 2023Article
- Inactivation of mammalian spermatozoa on the exposure of TiOJournal of analytical science and technology · 2023Article
- Light Triggered Enhancement of Antibiotic Efficacy in Biofilm Elimination Mediated by Gold-Silver Alloy Nanoparticles.Frontiers in microbiology · 2022Article
- ModifiedAnimals : an open access journal from MDPI · 2021Article
- Applications of omics and nanotechnology to improve pig embryo production in vitro.Molecular reproduction and development · 2019Review
- Nanoscale systems for local drug delivery.Nano today · 2019Article
- Protective effect of Zingerone against mouse testicular damage induced by zinc oxide nanoparticles.Environmental science and pollution research international · 2019Article
- Biologically produced silver chloride nanoparticles from B. megaterium modulate interleukin secretion by human adipose stem cell spheroids.Cytotechnology · 2018Article
- Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption.International journal of molecular sciences · 2018Article
- Sublethal Effects of Ionic and Nanogold on the NematodeJournal of toxicology · 2018Article
- Nanoparticles and female reproductive system: how do nanoparticles affect oogenesis and embryonic development.Oncotarget · 2017Review
- Efficient nucleic acid delivery to murine regulatory T cells by gold nanoparticle conjugates.Scientific reports · 2016Article
- Synthesis, characterization and in vitro effects of 7 nm alloyed silver-gold nanoparticles.Beilstein journal of nanotechnology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of engineered nanoparticles has risen exponentially over the last decade. Applications are manifold and include utilisation in industrial goods as well as medical and consumer products. Gold and silver nanoparticles play an important role in the current increase of nanoparticle usage. However, our understanding concerning possible side effects of this increased exposure to particles, which are frequently in the same size regime as medium sized biomolecules and accessorily possess highly active surfaces, is still incomplete. That particularly applies to reproductive aspects, were defects can be passed onto following generations. This review gives a brief overview of the most recent findings concerning reprotoxicological effects. The here presented data elucidate how composition, size and surface modification of nanoparticles influence viablility and functionality of reproduction relevant cells derived from various animal models. While in vitro cultured embryos displayed no toxic effects after the microinjection of gold and silver nanoparticles, sperm fertility parameters deteriorated after co-incubation with ligand free gold nanoparticles. However, the effect could be alleviated by bio-coating the nanoparticles, which even applies to silver and silver-rich alloy nanoparticles. The most sensitive test system appeared to be in vitro oocyte maturation showing a dose-dependent response towards protein (BSA) coated gold-silver alloy and silver nanoparticles leading up to complete arrest of maturation. Recent biodistribution studies confirmed that nanoparticles gain access to the ovaries and also penetrate the blood-testis and placental barrier. Thus, the design of nanoparticles with increased biosafety is highly relevant for biomedical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.