Evidence map›Paper›PMID 25821696›Full record

ReviewBeilstein journal of nanotechnology2015

Silica micro/nanospheres for theranostics: from bimodal MRI and fluorescent imaging probes to cancer therapy.

Shanka Walia, Amitabha Acharya

Open access · diamondAbstract readReview
In one paragraph

Review in Beilstein journal of nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

  1. Multifunctional Magnetic Resonance Imaging Probes.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026
    Review
  2. Recent Trends in Biomedical Applications of CuInternational journal of nanomedicine · 2025
    Review
  3. Article
  4. A dual-responsive probe for detecting cellular hypoxia usingChemical communications (Cambridge, England) · 2019
    Article
  5. Article
  6. Drug and gene delivery across the blood-brain barrier with focused ultrasound.Journal of controlled release : official journal of the Controlled Release Society · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Shanka WaliaBiotechnology Division, CSIR - Institute of Himalayan Bioresource Technology (CSIR - IHBT), Post Box No. 6, Palampur (H.P.) 176 061, India.
Amitabha AcharyaBiotechnology Division, CSIR - Institute of Himalayan Bioresource Technology (CSIR - IHBT), Post Box No. 6, Palampur (H.P.) 176 061, India.
Institute of Himalayan Bioresource Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nano-theranostics offer remarkable potential for future biomedical technology with simultaneous applications for diagnosis and therapy of disease sites. Through smart and careful chemical modifications of the nanoparticle surface, these can be converted to multifunctional tiny objects which in turn can be used as vehicle for delivering multimodal imaging agents and therapeutic material to specific target sites in vivo. In this sense, bimodal imaging probes that simultaneously enable magnetic resonance imaging and fluorescence imaging have gained tremendous attention because disease sites can be characterized quick and precisely through synergistic multimodal imaging. But such hybrid nanocomposite materials have limitations such as low chemical stability (magnetic component) and harsh cytotoxic effects (fluorescent component) and, hence, require a biocompatible protecting agent. Silica micro/nanospheres have shown promise as protecting agent due to the high stability and low toxicity. This review will cover a full description of MRI-active and fluorescent multifunctional silica micro/nanospheres including the design of the probe, different characterization methods and their application in imaging and treatment in cancer.

Indexed as

bimodal imagingfluorescence imagingmagnetic nanoparticlesorganic dyesquantum dotssilica nanospherestheranostics

Identifiers

PMID25821696
PMCPMC4361989
OpenAlexW1999633179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.