ArticleBeilstein journal of nanotechnology2015
A surface acoustic wave-driven micropump for particle uptake investigation under physiological flow conditions in very small volumes.
Article in Beilstein journal of nanotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Vibration enhanced cell growth induced by surface acoustic waves as in vitro wound-healing model.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cell Internalization in Fluidic Culture Conditions Is Improved When Microparticles Are Specifically Targeted to the Human Epidermal Growth Factor Receptor 2 (HER2).Pharmaceutics · 2019Article
- Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip.Diagnostics (Basel, Switzerland) · 2016Article
- Precise quantification of silica and ceria nanoparticle uptake revealed by 3D fluorescence microscopy.Beilstein journal of nanotechnology · 2014Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Static conditions represent an important shortcoming of many in vitro experiments on the cellular uptake of nanoparticles. Here, we present a versatile microfluidic device based on acoustic streaming induced by surface acoustic waves (SAWs). The device offers a convenient method for introducing fluid motion in standard cell culture chambers and for mimicking capillary blood flow. We show that shear rates over the whole physiological range in sample volumes as small as 200 μL can be achieved. A precise characterization method for the induced flow profile is presented and the influence of flow on the uptake of Pt-decorated CeO2 particles by endothelial cells (HMEC-1) is demonstrated. Under physiological flow conditions the particle uptake rates for this system are significantly lower than at low shear conditions. This underlines the vital importance of the fluidic environment for cellular uptake mechanisms.
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Registered trials
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