ArticleNeural plasticity2015
Cerebellar transcranial direct current stimulation effects on saccade adaptation.
Article in Neural plasticity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Targeting the Human Cerebellum with Transcranial Direct Current Stimulation to Modulate Behavior: a Meta-Analysis.Cerebellum (London, England) · 2018Pooled it
- A triple distinction of cerebellar function for oculomotor learning and fatigue compensation.PLoS computational biology · 2023Article
- No evidence for differential saccadic adaptation in children and adults with an autism spectrum diagnosis.Frontiers in integrative neuroscience · 2023Article
- Transcranial Direct-Current Stimulation Does Not Affect Implicit Sensorimotor Adaptation: A Randomized Sham-Controlled Trial.Brain sciences · 2022Article
- Investigating the effects of cerebellar transcranial direct current stimulation on saccadic adaptation and cortisol response.Cerebellum & ataxias · 2021Article
- Neural changes associated with cerebellar tDCS studied using MR spectroscopy.Experimental brain research · 2018Article
- Saccade adaptation deficits in developmental dyslexia suggest disruption of cerebellar-dependent learning.Journal of neurodevelopmental disorders · 2017Article
- Cerebellar patients do not benefit from cerebellar or M1 transcranial direct current stimulation during force-field reaching adaptation.Journal of neurophysiology · 2017Article
- No consistent effect of cerebellar transcranial direct current stimulation on visuomotor adaptation.Journal of neurophysiology · 2017Article
- Targeting the Cerebellum by Noninvasive Neurostimulation: a Review.Cerebellum (London, England) · 2017Review
- Impairment of Long-Term Plasticity of Cerebellar Purkinje Cells Eliminates the Effect of Anodal Direct Current Stimulation on Vestibulo-Ocular Reflex Habituation.Frontiers in neuroscience · 2017Article
- tDCS of the Cerebellum: Where Do We Stand in 2016? Technical Issues and Critical Review of the Literature.Frontiers in human neuroscience · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saccade adaptation is a cerebellar-mediated type of motor learning in which the oculomotor system is exposed to repetitive errors. Different types of saccade adaptations are thought to involve distinct underlying cerebellar mechanisms. Transcranial direct current stimulation (tDCS) induces changes in neuronal excitability in a polarity-specific manner and offers a modulatory, noninvasive, functional insight into the learning aspects of different brain regions. We aimed to modulate the cerebellar influence on saccade gains during adaptation using tDCS. Subjects performed an inward (n = 10) or outward (n = 10) saccade adaptation experiment (25% intrasaccadic target step) while receiving 1.5 mA of anodal cerebellar tDCS delivered by a small contact electrode. Compared to sham stimulation, tDCS increased learning of saccadic inward adaptation but did not affect learning of outward adaptation. This may imply that plasticity mechanisms in the cerebellum are different between inward and outward adaptation. TDCS could have influenced specific cerebellar areas that contribute to inward but not outward adaptation. We conclude that tDCS can be used as a neuromodulatory technique to alter cerebellar oculomotor output, arguably by engaging wider cerebellar areas and increasing the available resources for learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.