ArticleEvidence-based complementary and alternative medicine : eCAM2015
The Effect of Essential Oils and Bioactive Fractions on Streptococcus mutans and Candida albicans Biofilms: A Confocal Analysis.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Antibacterial Activity of Essential Oils and Their Isolated Constituents against Cariogenic Bacteria: A Systematic Review.Molecules (Basel, Switzerland) · 2015Pooled it
- The effect of Brazilian propolis type-3 against oral microbiota and volatile sulfur compounds in subjects with morning breath malodor.Clinical oral investigations · 2022Trial
- Cell Wall Proteome ofPathogens (Basel, Switzerland) · 2026Article
- Brazilian red propolis as a potential antimicrobial additive in orthodontic primers.Brazilian dental journal · 2025Article
- Cytocompatibility and Antibiofilm Activity of Calcium Hydroxide Mixed withAntibiotics (Basel, Switzerland) · 2024Article
- Antimicrobial Activity onPlants (Basel, Switzerland) · 2024Article
- Antimicrobial activity of Desplac® oral gel in the subgingival multispecies biofilm formation.Frontiers in microbiology · 2023Article
- Propolis, Aloe Vera, Green Tea, Cranberry, Calendula, Myrrha and Salvia Properties against Periodontal Microorganisms.Microorganisms · 2022Review
- Recent Updates on Microbial Biofilms in Periodontitis: An Analysis of In Vitro Biofilm Models.Advances in experimental medicine and biology · 2022Article
- Biological Properties ofEvidence-based complementary and alternative medicine : eCAM · 2022Review
- Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence.Dental materials : official publication of the Academy of Dental Materials · 2021Article
- Recombinant bacteriophage T4 Rnl1 impacts Streptococcus mutans biofilm formation.Journal of oral microbiology · 2020Article
- Article
- Management ofJournal of clinical medicine · 2020Review
- The Architecture of Monospecific Microalgae Biofilms.Microorganisms · 2019Article
- Effects ofJournal of clinical and experimental dentistry · 2018Article
- Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The essential oils (EO) and bioactive fractions (BF) from Aloysia gratissima, Baccharis dracunculifolia, Coriandrum sativum, Cyperus articulatus, and Lippia sidoides were proven to have strong antimicrobial activity on planktonic microorganisms; however, little is known about their effects on the morphology or viability of oral biofilms. Previously, we determined the EO/fractions with the best antimicrobial activity against Streptococcus mutans and Candida spp. In this report, we used a confocal analysis to investigate the effect of these EO and BF on the morphology of S. mutans biofilms (thickness, biovolume, and architecture) and on the metabolic viability of C. albicans biofilms. The analysis of intact treated S. mutans biofilms showed no statistical difference for thickness in all groups compared to the control. However, a significant reduction in the biovolume of extracellular polysaccharides and bacteria was observed for A. gratissima and L. sidoides groups, indicating that these BF disrupt biofilm integrity and may have created porosity in the biofilm. This phenomenon could potentially result in a weakened structure and affect biofilm dynamics. Finally, C. sativum EO drastically affected C. albicans viability when compared to the control. These results highlight the promising antimicrobial activity of these plant species and support future translational research on the treatment of dental caries and oral candidiasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.