Evidence map›Paper›PMID 25821495›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2015

Maslinic Acid enhances signals for the recruitment of macrophages and their differentiation to m1 state.

Cristina Sánchez-Quesada, Alicia López-Biedma, José J Gaforio

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
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  7. Review
  8. Article
  9. Squalene Stimulates a Key Innate Immune Cell to Foster Wound Healing and Tissue Repair.Evidence-based complementary and alternative medicine : eCAM · 2018
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Cristina Sánchez-QuesadaImmunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaen, Campus las Lagunillas, s/n, 23071 Jaén, Spain ; Centro de Estudios Avanzados en Olivar y Aceites de Oliva, Parque Científico-Tecnológico Geolit, c/ Sierra Morena, Edificio CTSA Módulo 1, Mengíbar, 23620 Jaén, Spain ; Agrifood Campus of International Excellence (ceiA3), University of Jaén, Campus Las Lagunillas, s/n, 23071 Jaén, Spain.ORCID 0000-0003-2997-8515
Alicia López-BiedmaImmunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaen, Campus las Lagunillas, s/n, 23071 Jaén, Spain ; Centro de Estudios Avanzados en Olivar y Aceites de Oliva, Parque Científico-Tecnológico Geolit, c/ Sierra Morena, Edificio CTSA Módulo 1, Mengíbar, 23620 Jaén, Spain ; Agrifood Campus of International Excellence (ceiA3), University of Jaén, Campus Las Lagunillas, s/n, 23071 Jaén, Spain.ORCID 0000-0001-9518-3409
José J GaforioImmunology Division, Department of Health Sciences, Faculty of Experimental Sciences, University of Jaen, Campus las Lagunillas, s/n, 23071 Jaén, Spain ; Centro de Estudios Avanzados en Olivar y Aceites de Oliva, Parque Científico-Tecnológico Geolit, c/ Sierra Morena, Edificio CTSA Módulo 1, Mengíbar, 23620 Jaén, Spain ; Agrifood Campus of International Excellence (ceiA3), University of Jaén, Campus Las Lagunillas, s/n, 23071 Jaén, Spain.
Universidad de Jaén · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inflammatory process is involved in the genesis and evolution of different diseases like obesity, cardiovascular disease, and cancer. Macrophages play a central role in inflammation. In addition, they can regulate some stages of cancer development. Macrophages can polarize into M1 or M2 functional phenotype depending on the cytokines present in the tissue microenvironment. On the other hand, triterpenes found in virgin olive oil are described to present different properties, such as antitumoral and anti-inflammatory activity. The present study was designed to elucidate if the four major triterpenes found in virgin olive oil (oleanolic acid, maslinic acid, uvaol, and erythrodiol) are able to enhance M1 macrophage response which represents an important defense mechanism against cancer. Our results indicated that maslinic acid modulated the inflammatory response by enhancing the production of IL-8, IL-1α, and IL-1β; it promoted M1 response through the synthesis of IFN-γ; and finally it did not modify significantly the levels of NFκβ or NO. Overall, our results showed that maslinic acid could prevent chronic inflammation, which represents a crucial step in the development of some cancers.

Identifiers

PMID25821495
PMCPMC4364129
OpenAlexW2030720740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.