ArticleEvidence-based complementary and alternative medicine : eCAM2015
Hepatoprotective Effect of Silymarin (Silybum marianum) on Hepatotoxicity Induced by Acetaminophen in Spontaneously Hypertensive Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 77 citations in OpenAlex.
- α-Linolenic acid-driven nano-liposomes from purslane seed oil modulate p-JAK2/p-STAT3 to combat acute liver failure.Bioscience reports · 2026Article
- Targeting metabolic dysfunction-associated steatotic liver disease with phytosomal silymarin and piperine: A natural alternative to fenofibrate in a rat model.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Metabolic profiling of milk thistle different organs using UPLC-TQD-MS/MS coupled to multivariate analysis in relation to their selective antiviral potential.BMC complementary medicine and therapies · 2024Article
- Evaluation of hepatoprotective and antidiarrheal activities of the hydromethanol crude extract and solvent fractions ofMetabolism open · 2024Article
- Review
- The Antioxidant and Hepatoprotective Potential of Berberine and Silymarin on Acetaminophen Induced Toxicity inAnimals : an open access journal from MDPI · 2024Article
- Exploring the hepatoprotective properties of citronellol:Open life sciences · 2024Article
- Pathological Role of Oxidative Stress in Aflatoxin-Induced Toxicity in Different Experimental Models and Protective Effect of Phytochemicals: A Review.Molecules (Basel, Switzerland) · 2023Review
- Potential Curative Effects of Aqueous Extracts ofCurrent therapeutic research, clinical and experimental · 2023Article
- Enhancement of the Protective Activity of Vanillic Acid against Tetrachloro-Carbon (CClMolecules (Basel, Switzerland) · 2022Article
- JNK and p38 gene and protein expression during liver ischemia-reperfusion in a rat model treated with silibinin.Iranian journal of basic medical sciences · 2022Article
- Mechanistic Insights into the Pharmacological Significance of Silymarin.Molecules (Basel, Switzerland) · 2022Review
- Silymarin constrains diacetyl-prompted oxidative stress and neuroinflammation in rats: involvements of Dyn/GDNF and MAPK signaling pathway.Inflammopharmacology · 2022Article
- Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells.Journal of the Chinese Medical Association : JCMA · 2022Article
- Hepatoprotective effect ofPharmaceutical biology · 2021Article
- A Comparative Study of the Hepatoprotective Effect ofNutrients · 2021Article
- Sage,Molecules (Basel, Switzerland) · 2021Article
- Green coffee methanolic extract and silymarin protect against CCl4-induced hepatotoxicity in albino male rats.BMC complementary medicine and therapies · 2021Article
- Antioxidant, anti-inflammatory and hepatoprotective activities ofToxicology reports · 2021Article
- Role of Nutraceuticals in COVID-19 Mediated Liver Dysfunction.Molecules (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study was aimed to investigate the effect of Silymarin (SLM) on the hypertension state and the liver function changes induced by acetaminophen (APAP) in spontaneously hypertensive rat (SHR). Animals normotensive (N) or hypertensive (SHR) were treated or not with APAP (3 g/kg, oral) or previously treated with SLM. Twelve hours after APAP administration, plasmatic levels of liver function markers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), glucose (GLU), gamma glutamyl transferase (γ-GT), and alkaline phosphatase (ALP) of all groups, were determined. Liver injury was assessed using histological studies. Samples of their livers were then used to determine the myeloperoxidase (MPO) activity and nitric oxide (NO) production and were also sectioned for histological analysis. No differences were observed for ALT, γ-GT, and GLU levels between SHR and normotensive rats groups. However, AST and ALP levels were increased in hypertensive animals. APAP treatment promoted an increase in ALT and AST in both SHR and N. However, only for SHR, γ-GT levels were increased. The inflammatory response evaluated by MPO activity and NO production showed that SHR was more susceptible to APAP effect, by increasing leucocyte infiltration. Silymarin treatment (Legalon) restored the hepatocyte functional and histopathological alterations induced by APAP in normotensive and hypertensive animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.