Evidence map›Paper›PMID 25821424›Full record

ArticlePostepy dermatologii i alergologii2015

The role of selectins in alopecia areata.

Wiesława Sudnik, Aleksandra Dańczak-Pazdrowska, Wojciech Silny, Agnieszka Osmola-Mańkowska, Jakub Pazdrowski, Adriana Polańska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Postepy dermatologii i alergologii, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Wiesława SudnikDepartment of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Zygmunt Adamski MD, PhD.
Aleksandra Dańczak-PazdrowskaDepartment of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Zygmunt Adamski MD, PhD.
Wojciech SilnyGreat Poland Center of Allergology and Aesthetic Dermatology "Art Clinic", Poznan, Poland. Head of Center: Prof. Wojciech Silny MD, PhD.
Agnieszka Osmola-MańkowskaDepartment of Dermatology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Zygmunt Adamski MD, PhD.
Jakub PazdrowskiDepartment of Head and Neck Surgery, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Wojciech Golusiński MD, PhD.
Adriana PolańskaDepartment of Dermatology and Venereology, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ryszard Żaba MD, PhD.
Poznan University of Medical Sciences · PLAesthetic Surgery Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOne of the main histopathological features of alopecia areata (AA) is a lymphocytic infiltration that surrounds hair follicles. Soluble forms of E, L, P-selectins are known indicators of ongoing inflammation. There are no studies regarding the assessment of their contribution in AA.

aimTo assess serum concentrations of selectins (E-selectin, L-selectin and P-selectin) in patients with AA in relation to selected clinical parameters, including disease severity and activity. MATERIAL AND

methodsSixty-four patients with AA were involved in the study. The diagnosis was based on physical examination and photodermoscopy. The control group consisted of 40 healthy subjects. The serum concentrations of soluble E-selectin, L-selectin and P-selectin were detected with ELISA method.

resultsStatistically significantly higher levels of E, P, L-selectins were found in AA patients as compared with the healthy group. Serum concentrations of soluble forms of E- and L-selectins correlated with the severity of the disease, while E-selectin with activity of AA.

conclusionsThis study shows that selectins may play an important role in the pathogenesis of AA and may be a target of future therapies in this disease.

Indexed as

alopecia areataE-selectinL-selectinP-selectin

Identifiers

PMID25821424
PMCPMC4360002
OpenAlexW2111666558

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.