Evidence map›Paper›PMID 25821339›Full record

ArticleDisease markers2015

Capillary deposition of complement C4d and C3d in Chinese renal allograft biopsies.

Rong Lv, Wei Zhang, Fei Han, Guangjun Liu, Wenqing Xie, Jianghua Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rong LvKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Nephropathy, Hangzhou, Zhejiang 310003, China ; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, Zhejiang 310003, China.
Wei ZhangKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Nephropathy, Hangzhou, Zhejiang 310003, China ; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, Zhejiang 310003, China.
Fei HanKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Nephropathy, Hangzhou, Zhejiang 310003, China ; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, Zhejiang 310003, China.
Guangjun LiuKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Nephropathy, Hangzhou, Zhejiang 310003, China ; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, Zhejiang 310003, China.
Wenqing XieKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Nephropathy, Hangzhou, Zhejiang 310003, China ; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, Zhejiang 310003, China.
Jianghua ChenKidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Nephropathy, Hangzhou, Zhejiang 310003, China ; Kidney Disease Immunology Laboratory, The Third Grade Laboratory, State Administration of Traditional Chinese Medicine, Hangzhou, Zhejiang 310003, China ; Key Laboratory of Multiple Organ Transplantation, Ministry of Health, Hangzhou, Zhejiang 310003, China.ORCID 0000-0002-3282-3998
State Administration of Traditional Chinese Medicine of the People's Republic of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundC3d is a product of both the classic and the alternative complement cascades; however, few studies have addressed the role of C3d in renal biopsies and its relationship with long-term graft survival rate is not very clear.

methods94 patients with biopsy-proven acute rejection episodes were included in the study. We investigated the associations between histological findings, clinical examinations, and outcome.

resultsThe overall prevalence for C4dPTC and C3dPTC was 42.6% and 29.8%. There was a significant association between C3dPTC and C4dPTC (P < 0.001). C3dPTC and C4dPTC were related with histological types (P = 0.024 and P < 0.001, resp.). The long-term survival rate for C4dPTC positive transplants was lower than that of C4dPTC negative transplants, but it was not statistic significant in our study (P = 0.150). The survival rate of C3dPTC positive group was much lower than the negative group (P = 0.014). Patients with double positives for C4dPTC and C3dPTC exhibited the lowest survival rate significantly different from those of the C3dPTC only and C4dPTC only groups (P = 0.01 and P = 0.0037).

conclusionsThis longitudinal cohort study has demonstrated that C3d deposition in the PTC was closely related to renal dysfunction and pathological changes.

Indexed as

AdultAllograftsCapillariesComplement C3dComplement C4bFemaleGraft RejectionHumansKidney TransplantationMaleMiddle AgedPeptide FragmentsComplement C3dComplement C4bcomplement C4dPeptide Fragments

Identifiers

PMID25821339
PMCPMC4364125
OpenAlexW2095568916

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.