ArticleHuman brain mapping2015
Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Biological aging in childhood and adolescence following experiences of threat and deprivation: A systematic review and meta-analysis.Psychological bulletin · 2020Pooled it
- The ICCAM platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part B: fMRI description.Journal of psychopharmacology (Oxford, England) · 2017Pooled it
- Reliability of mismatch negativity event-related potentials in a multisite, traveling subjects study.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020Trial
- Blunted amygdala activity is associated with depression severity in treatment-resistant depression.Cognitive, affective & behavioral neuroscience · 2017Trial
- Regulating Negative Autobiographical Memories: An fMRI Investigation of Reappraisal and Distraction in Middle-aged and Older Adults.Journal of cognitive neuroscience · 2026Article
- Investigating Neural Correlates of Emotional Regulation as a Function of Age, Race, and Socioeconomic Status.bioRxiv : the preprint server for biology · 2025Article
- Investigative Approaches to Resilient Emotion Regulation Neurodevelopment in a South African Birth Cohort.Biological psychiatry global open science · 2025Article
- Advances in Neuroimaging and Deep Learning for Emotion Detection: A Systematic Review of Cognitive Neuroscience and Algorithmic Innovations.Diagnostics (Basel, Switzerland) · 2025Review
- Neural and affective responses to prolonged eye contact with parents in depressed and nondepressed adolescents.Cognitive, affective & behavioral neuroscience · 2024Article
- Free-viewing gaze patterns reveal a mood-congruency bias in MDD during an affective fMRI/eye-tracking task.European archives of psychiatry and clinical neuroscience · 2024Observational
- A precision neuroscience approach to estimating reliability of neural responses during emotion processing: Implications for task-fMRI.NeuroImage · 2024Article
- Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1.Human brain mapping · 2023Article
- Circadian Variation of Migraine Attack Onset Affects fMRI Brain Response to Fearful Faces.Frontiers in human neuroscience · 2022Article
- The instability of functional connectomes across the first year of life.Developmental cognitive neuroscience · 2021Article
- Comparison of Four fMRI Paradigms Probing Emotion Processing.Brain sciences · 2021Article
- Automatic identification of atypical clinical fMRI results.Neuroradiology · 2020Article
- Low Emotional Awareness as a Transdiagnostic Mechanism Underlying Psychopathology in Adolescence.Clinical psychological science : a journal of the Association for Psychological Science · 2020Article
- Expected value and sensitivity to punishment modulate insular cortex activity during risky decision making.Scientific reports · 2020Article
- Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms.Neurobiology of stress · 2020Article
- A Neglected Topic in Neuroscience: Replicability of fMRI Results With Specific Reference to ANOREXIA NERVOSA.Frontiers in psychiatry · 2020Article
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Authors and funding
24 authors at 10 institutions in 2 countries.
Funding
Abstract
Multisite neuroimaging studies can facilitate the investigation of brain-related changes in many contexts, including patient groups that are relatively rare in the general population. Though multisite studies have characterized the reliability of brain activation during working memory and motor functional magnetic resonance imaging tasks, emotion processing tasks, pertinent to many clinical populations, remain less explored. A traveling participants study was conducted with eight healthy volunteers scanned twice on consecutive days at each of the eight North American Longitudinal Prodrome Study sites. Tests derived from generalizability theory showed excellent reliability in the amygdala ( Eρ2 = 0.82), inferior frontal gyrus (IFG; Eρ2 = 0.83), anterior cingulate cortex (ACC; Eρ2 = 0.76), insula ( Eρ2 = 0.85), and fusiform gyrus ( Eρ2 = 0.91) for maximum activation and fair to excellent reliability in the amygdala ( Eρ2 = 0.44), IFG ( Eρ2 = 0.48), ACC ( Eρ2 = 0.55), insula ( Eρ2 = 0.42), and fusiform gyrus ( Eρ2 = 0.83) for mean activation across sites and test days. For the amygdala, habituation ( Eρ2 = 0.71) was more stable than mean activation. In a second investigation, data from 111 healthy individuals across sites were aggregated in a voxelwise, quantitative meta-analysis. When compared with a mixed effects model controlling for site, both approaches identified robust activation in regions consistent with expected results based on prior single-site research. Overall, regions central to emotion processing showed strong reliability in the traveling participants study and robust activation in the aggregation study. These results support the reliability of blood oxygen level-dependent signal in emotion processing areas across different sites and scanners and may inform future efforts to increase efficiency and enhance knowledge of rare conditions in the population through multisite neuroimaging paradigms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.