ArticleAnnals of biomedical engineering2015
Patient-Specific Airway Wall Remodeling in Chronic Lung Disease.
Article in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Wall stiffening is a primary contributor to motility loss in Crohn's disease: an electromechanical modeling study.bioRxiv : the preprint server for biology · 2026Article
- Programmable Tissue Folding Patterns in Structured Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Digital twins for chronic lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Effects of tissue degradation by collagenase and elastase on the biaxial mechanics of porcine airways.Respiratory research · 2023Article
- Morphometric analysis of airways in pre-COPD and mild COPD lungs using continuous surface representations of the bronchial lumen.Frontiers in bioengineering and biotechnology · 2023Article
- PDE-constrained shape registration to characterize biological growth and morphogenesis from imaging data.Engineering with computers · 2022Article
- Associating local strains to global pressure-volume mouse lung mechanics using digital image correlation.Physiological reports · 2022Article
- Patient-specific finite element analysis of heart failure and the impact of surgical intervention in pulmonary hypertension secondary to mitral valve disease.Medical & biological engineering & computing · 2022Article
- Mouse lung mechanical properties under varying inflation volumes and cycling frequencies.Scientific reports · 2022Article
- Examining lung mechanical strains as influenced by breathing volumes and rates using experimental digital image correlation.Respiratory research · 2022Article
- Reduced biomechanical models for precision-cut lung-slice stretching experiments.Journal of mathematical biology · 2021Article
- Developing a Lung Model in the Age of COVID-19: A Digital Image Correlation and Inverse Finite Element Analysis Framework.Frontiers in bioengineering and biotechnology · 2021Review
- Three-Dimensional Whole-Organ Characterization of the Regional Alveolar Morphology in Normal Murine Lungs.Frontiers in physiology · 2021Article
- Biomechanical Force Prediction for Lengthening of Small Intestine during Distraction Enterogenesis.Bioengineering (Basel, Switzerland) · 2020Article
- Propagation of uncertainty in the mechanical and biological response of growing tissues using multi-fidelity Gaussian process regression.Computer methods in applied mechanics and engineering · 2020Article
- Novel Mechanical Strain Characterization of VentilatedFrontiers in physiology · 2020Article
- Introducing a Custom-Designed Volume-Pressure Machine for Novel Measurements of Whole Lung Organ Viscoelasticity and Direct Comparisons Between Positive- and Negative-Pressure Ventilation.Frontiers in bioengineering and biotechnology · 2020Article
- Mechanics of pulmonary airways: Linking structure to function through constitutive modeling, biochemistry, and histology.Acta biomaterialia · 2019Article
- Evaluation of Ventilation-Induced Lung Inflammation Through Multi-Scale Simulations.IEEE journal of translational engineering in health and medicine · 2018Article
- The effect of disease and respiration on airway shape in patients with moderate persistent asthma.PloS one · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chronic lung disease affects more than a quarter of the adult population; yet, the mechanics of the airways are poorly understood. The pathophysiology of chronic lung disease is commonly characterized by mucosal growth and smooth muscle contraction of the airways, which initiate an inward folding of the mucosal layer and progressive airflow obstruction. Since the degree of obstruction is closely correlated with the number of folds, mucosal folding has been extensively studied in idealized circular cross sections. However, airflow obstruction has never been studied in real airway geometries; the behavior of imperfect, non-cylindrical, continuously branching airways remains unknown. Here we model the effects of chronic lung disease using the nonlinear field theories of mechanics supplemented by the theory of finite growth. We perform finite element analysis of patient-specific Y-branch segments created from magnetic resonance images. We demonstrate that the mucosal folding pattern is insensitive to the specific airway geometry, but that it critically depends on the mucosal and submucosal stiffness, thickness, and loading mechanism. Our results suggests that patient-specific airway models with inherent geometric imperfections are more sensitive to obstruction than idealized circular models. Our models help to explain the pathophysiology of airway obstruction in chronic lung disease and hold promise to improve the diagnostics and treatment of asthma, bronchitis, chronic obstructive pulmonary disease, and respiratory failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.