Evidence map›Paper›PMID 25821061›Full record

SynthesisHuman brain mapping2015

Human pulvinar functional organization and connectivity.

Daniel S Barron, Simon B Eickhoff, Mareike Clos, Peter T Fox

Open access · greenAbstract readMeta-Analysis
In one paragraph

Synthesis in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.

  1. Pooled it
  2. A Direct Auditory Subcortical Route to the Amygdala Associated with Fear in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Review
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  18. Subcortical contributions to the sense of body ownership.Brain : a journal of neurology · 2024
    Article
  19. Multiple focal pulvinar projection fields in the macaque cortex.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 3 countries.

Daniel S BarronResearch Imaging Institute, University of Texas Health Science Center at San Antonio, Texas, USA.
Simon B EickhoffInstitute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
Mareike ClosInstitute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Düsseldorf, Germany.
Peter T FoxResearch Imaging Institute, University of Texas Health Science Center at San Antonio, Texas, USA.
Heinrich Heine University Düsseldorf · DESouth Texas Veterans Health Care System · USThe University of Texas Health Science Center at San Antonio · USUniversity Medical Center Hamburg-Eppendorf · DE

Funding

Meta-anaylsis in human brain mappingR01MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2006 to 2024
$10.5M
Meta-analysis in human brain mappingR56MH074457 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI FOX, PETER THORNTON · 2020 to 2020
$543k
Quantification of Thalamic Atrophy and Connectivity in Medial Temporal Lobe EpileF31NS083160 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BARRON, DANIEL S. · 2013 to 2014
$33k
NIMH NIH HHS R01 MH074457NIMH NIH HHS R01-MH074457NIMH NIH HHS R56 MH074457NINDS NIH HHS 1-F31-NS083160-01NINDS NIH HHS F31 NS083160
6 · The paper itself

Abstract

The human pulvinar is the largest thalamic area in terms of size and cortical connectivity. Although much is known about regional pulvinar structural anatomy, relatively little is known about pulvinar functional anatomy in humans. Cooccurrence of experimentally induced brain activity is a traditional metric used to establish interregional brain connectivity and forms the foundation of functional neuroimaging connectivity analyses. Because functional neuroimaging studies report task-related coactivations within a standardized space, meta-analysis of many whole-brain studies can define the brain's interregional coactivation across many tasks. Such an analysis can also detect and define variations in functional coactivations within a particular region. Here we use coactivation profiles reported in ∼ 7,700 functional neuroimaging studies to parcellate and define the pulvinar's functional anatomy. Parcellation of the pulvinar's coactivation profile identified five clusters per pulvinar of distinct functional coactivation. These clusters showed a high degree of symmetry across hemispheres and correspondence with the human pulvinar's cytoarchitecture. We investigated the functional coactivation profiles of each resultant pulvinar cluster with meta-analytic methods. By referencing existent neuroimaging and lesion-deficit literature, these profiles make a case for regional pulvinar specialization within the larger human attention-controlling network. Reference to this literature also informs specific hypotheses that can be tested in subsequent studies in healthy and clinical populations.

Indexed as

Brain MappingHumansNerve NetPulvinarattentioncognitive neurosciencefMRIfunctional anatomypulvinar

Identifiers

PMID25821061
PMCPMC4782796
OpenAlexW1836802875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.