Evidence map›Paper›PMID 25820989›Full record

ArticleClinical oral investigations2015

Calcium silicate/calcium phosphate biphasic cements for vital pulp therapy: chemical-physical properties and human pulp cells response.

M G Gandolfi, G Spagnuolo, F Siboni, A Procino, V Rivieccio, G A Pelliccioni, C Prati, S Rengo

Abstract read
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In one paragraph

Article in Clinical oral investigations, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 100 citations in OpenAlex.

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  17. Evaluation and comparison of cytotoxicity and bioactivity of chemomechanical caries removal agents on stem cells from human exfoliated deciduous teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

M G GandolfiDental School (Laboratory of Biomaterials and Oral Pathology), Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy. mgiovanna.gandolfi@unibo.it.
G SpagnuoloDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Napoli, Italy.
F SiboniDental School (Laboratory of Biomaterials and Oral Pathology), Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
A ProcinoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Napoli, Italy.
V RivieccioDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Napoli, Italy.
G A PelliccioniDental School (Laboratory of Biomaterials and Oral Pathology), Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
C PratiDental School (Laboratory of Biomaterials and Oral Pathology), Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.
S RengoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", Napoli, Italy.
University of Bologna · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim was to test the properties of experimental calcium silicate/calcium phosphate biphasic cements with hydraulic properties designed for vital pulp therapy as direct pulp cap and pulpotomy.

methodsCaSi-αTCP and CaSi-DCDP were tested for ion-releasing ability, solubility, water sorption, porosity, ability to nucleate calcium phosphates, and odontoblastic differentiation—alkaline phosphatase (ALP) and osteocalcin (OCN) upregulation—of primary human dental pulp cells (HDPCs).

resultsThe materials showed high Ca and OH release, high open pore volume and apparent porosity, and a pronounced ability to nucleate calcium phosphates on their surface. HDPCs treated with CaSi-αTCP showed a strong upregulation of ALP and OCN genes, namely a tenfold increase for OCN and a threefold increase for ALP compared to the control cells. Conversely, CaSi-DCDP induced a pronounced OCN gene upregulation but had no effect on ALP gene regulation.

conclusionsBoth cements showed high biointeractivity (release of Ca and OH ions) correlated with their marked ability to nucleate calcium phosphates. CaSi-αTCP cement proved to be a potent inducer of ALP and OCN genes as characteristic markers of mineralization processes normally poorly expressed by HDPCs. CLINICAL RELEVANCE: Calcium silicate/calcium phosphate cements appear to be attractive new materials for vital pulp therapy as they may provide odontogenic/dentinogenic chemical signals for pulp regeneration and healing, and dentin formation in regenerative endodontics.

Indexed as

Materials TestingCalcium CompoundsCalcium PhosphatesCells, CulturedDental CementsDental PulpHumansSilicatesCalcium Compoundscalcium phosphateCalcium Phosphatescalcium silicateDental CementsSilicatesAlkaline phosphataseBiointeractivityCalcium phosphate cementsCalcium releaseCalcium silicate cementsDentine regenerationGenes activationMTAOsteocalcinpHPorosityPulp cellsPulp therapyRegenerative dentistrySolubility

Identifiers

PMID25820989
OpenAlexW2040045905

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.