Evidence map›Paper›PMID 25820840›Full record

ArticleThe international journal of neuropsychopharmacology2015

Pretreatment Differences in BOLD Response to Emotional Faces Correlate with Antidepressant Response to Scopolamine.

Maura L Furey, Wayne C Drevets, Joanna Szczepanik, Ashish Khanna, Allison Nugent, Carlos A Zarate

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Maura L FureyExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute on Mental Health, National Institutes of Health, Bethesda, MD (Dr Furey, Ms Szczepanik, Dr Nugent, and Dr Zarate); Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ (Dr Drevets); Physical Medicine & Rehabilitation, Jewish Medical Center, Brooklyn Hospital Center, Brooklyn, NY (Dr Khanna).Registry number NCT00055575. mfurey@mail.nih.gov.
Wayne C DrevetsExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute on Mental Health, National Institutes of Health, Bethesda, MD (Dr Furey, Ms Szczepanik, Dr Nugent, and Dr Zarate); Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ (Dr Drevets); Physical Medicine & Rehabilitation, Jewish Medical Center, Brooklyn Hospital Center, Brooklyn, NY (Dr Khanna).Registry number NCT00055575.
Joanna SzczepanikExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute on Mental Health, National Institutes of Health, Bethesda, MD (Dr Furey, Ms Szczepanik, Dr Nugent, and Dr Zarate); Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ (Dr Drevets); Physical Medicine & Rehabilitation, Jewish Medical Center, Brooklyn Hospital Center, Brooklyn, NY (Dr Khanna).Registry number NCT00055575.
Ashish KhannaExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute on Mental Health, National Institutes of Health, Bethesda, MD (Dr Furey, Ms Szczepanik, Dr Nugent, and Dr Zarate); Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ (Dr Drevets); Physical Medicine & Rehabilitation, Jewish Medical Center, Brooklyn Hospital Center, Brooklyn, NY (Dr Khanna).Registry number NCT00055575.
Allison NugentExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute on Mental Health, National Institutes of Health, Bethesda, MD (Dr Furey, Ms Szczepanik, Dr Nugent, and Dr Zarate); Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ (Dr Drevets); Physical Medicine & Rehabilitation, Jewish Medical Center, Brooklyn Hospital Center, Brooklyn, NY (Dr Khanna).Registry number NCT00055575.
Carlos A ZarateExperimental Therapeutics and Pathophysiology Branch, Intramural Research Program, National Institute on Mental Health, National Institutes of Health, Bethesda, MD (Dr Furey, Ms Szczepanik, Dr Nugent, and Dr Zarate); Janssen Pharmaceuticals, LLC, of Johnson & Johnson, Inc., Titusville, NJ (Dr Drevets); Physical Medicine & Rehabilitation, Jewish Medical Center, Brooklyn Hospital Center, Brooklyn, NY (Dr Khanna).Registry number NCT00055575.
Johnson & Johnson (United States) · USNational Institute of Mental Health · USBrooklyn Hospital Center · US

Funding

Glutamatergic Modulators for Rapid & Sustained Antidepressant EffectZIAMH002857 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2009 to 2025
$55.0M
Target validation of novel therapeutic agents in mood disordersZIAMH002927 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI ZARATE, CARLOS · 2010 to 2025
$37.1M
6 · The paper itself

Abstract

backgroundFaster acting antidepressants and biomarkers that predict treatment response are needed to facilitate the development of more effective treatments for patients with major depressive disorders. Here, we evaluate implicitly and explicitly processed emotional faces using neuroimaging to identify potential biomarkers of treatment response to the antimuscarinic, scopolamine.

methodsHealthy participants (n=15) and unmedicated-depressed major depressive disorder patients (n=16) participated in a double-blind, placebo-controlled crossover infusion study using scopolamine (4 μg/kg). Before and following scopolamine, blood oxygen-level dependent signal was measured using functional MRI during a selective attention task. Two stimuli comprised of superimposed pictures of faces and houses were presented. Participants attended to one stimulus component and performed a matching task. Face emotion was modulated (happy/sad) creating implicit (attend-houses) and explicit (attend-faces) emotion processing conditions. The pretreatment difference in blood oxygen-level dependent response to happy and sad faces under implicit and explicit conditions (emotion processing biases) within a-priori regions of interest was correlated with subsequent treatment response in major depressive disorder.

resultsCorrelations were observed exclusively during implicit emotion processing in the regions of interest, which included the subgenual anterior cingulate (P<.02) and middle occipital cortices (P<.02).

conclusionsThe magnitude and direction of differential blood oxygen-level- dependent response to implicitly processed emotional faces prior to treatment reflect the potential to respond to scopolamine. These findings replicate earlier results, highlighting the potential for pretreatment neural activity in the middle occipital cortices and subgenual anterior cingulate to inform us about the potential to respond clinically to scopolamine.

Indexed as

AdultAntidepressive AgentsAttentionBrainBrain MappingCerebrovascular CirculationCross-Over StudiesDouble-Blind MethodEmotionsFacial RecognitionFemaleHumansMagnetic Resonance ImagingMajor Depressive DisorderMaleNeuropsychological TestsAntidepressive AgentsOxygenScopolamineanticholinergicantimuscarinicBiomarkermood disorders

Identifiers

PMID25820840
PMCPMC4571629
OpenAlexW2116855542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.