ArticleMovement disorders : official journal of the Movement Disorder Society2015
T1ρ imaging in premanifest Huntington disease reveals changes associated with disease progression.
Article in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Cognition-oriented treatments and physical exercise on cognitive function in Huntington's disease: a systematic review.Journal of neurology · 2023Pooled it
- Hippocampal acidity and volume are differentially associated with spatial navigation in older adults.NeuroImage · 2021Article
- Moderate Intensity Exercise in Pre-manifest Huntington's Disease: Results of a 6 months Trial.SVOA neurology · 2021Article
- Three-Dimensional GRE TMagnetic resonance in medicine · 2020Article
- Subcortical T1-Rho MRI Abnormalities in Juvenile-Onset Huntington's Disease.Brain sciences · 2020Article
- R1ρ sensitivity to pH and other compounds at clinically accessible spin-lock fields in the presence of proteins.NMR in biomedicine · 2020Article
- Proton Exchange Magnetic Resonance Imaging: Current and Future Applications in Psychiatric Research.Frontiers in psychiatry · 2020Review
- Comparison of TThe Journal of neuropsychiatry and clinical neurosciences · 2020Article
- COX REGRESSION WITH EXCLUSION FREQUENCY-BASED WEIGHTS TO IDENTIFY NEUROIMAGING MARKERS RELEVANT TO HUNTINGTON'S DISEASE ONSET.The annals of applied statistics · 2016Article
- Huntington disease: cerebrospinal fluid and MRI biomarkers for prodromal HD.Nature reviews. Neurology · 2015Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundImaging biomarkers sensitive to Huntington's disease (HD) during the premanifest phase preceding motor diagnosis may accelerate identification and evaluation of potential therapies. For this purpose, quantitative MRI sensitive to tissue microstructure and metabolism may hold great potential. We investigated the potential value of T1ρ relaxation to detect pathological changes in premanifest HD (preHD) relative to other quantitative relaxation parameters.
methodsQuantitative MR parametric mapping was used to assess differences between 50 preHD subjects and 26 age- and sex-matched controls. Subjects with preHD were classified into two progression groups based on their CAG-age product (CAP) score; a high and a low/moderate CAP group. Voxel-wise and region-of-interest analyses were used to assess changes in the quantitative relaxation times.
resultsT1ρ showed a significant increase in the relaxation times in the high-CAP group, as compared to controls, largely in the striatum. The T1ρ changes in the preHD subjects showed a significant relationship with CAP score. No significant changes in T2 or T2* relaxation times were found in the striatum. T2* relaxation changes were found in the globus pallidus, but no significant changes with disease progression were found.
conclusionThese data suggest that quantitative T1ρ mapping may provide a useful marker for assessing disease progression in HD. The absence of T2 changes suggests that the T1ρ abnormalities are unlikely owing to altered water content or tissue structure. The established sensitivity of T1ρ to pH and glucose suggests that these factors are altered in HD perhaps owing to abnormal mitochondrial function.
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