Evidence map›Paper›PMID 25820745›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015

Education, marital status, and risk of hip fractures in older men and women: the CHANCES project.

V Benetou, P Orfanos, D Feskanich, K Michaëlsson, U Pettersson-Kymmer, L A Ahmed, A Peasey, A Wolk, H Brenner, M Bobak and 10 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Socio-economic inequalities in fragility fracture incidence: a systematic review and meta-analysis of 61 observational studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
    Pooled it
  2. Risk Factors for Hip Fracture in Older Men: The Osteoporotic Fractures in Men Study (MrOS).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Trial
  3. Article
  4. Educational gradient in hip fracture incidence in Norway. The Norwegian Epidemiologic Osteoporosis Studies (NOREPOS).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Article
  5. Observational
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  10. Differences in hospital length of stay and total hospital charge by income level in patients hospitalized for hip fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  11. Article
  12. The Widowhood Effect on Mortality in Older Patients with Hip Fracture.International journal of general medicine · 2022
    Article
  13. Risk Factors Associated With Hip Fractures among Adult People in Babylon City, Iraq.Open access Macedonian journal of medical sciences · 2019
    Article
  14. Comments on Feskanich et al.: Milk and other dairy foods and risk of hip fracture in men and women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Article
  15. Demographic Study of Hip Fractures in the Maltese Islands.Geriatric orthopaedic surgery & rehabilitation · 2018
    Article
  16. Article
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  19. Socioeconomic inequality in clinical outcome among hip fracture patients: a nationwide cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  20. Men's health-seeking behaviours regarding bone health after a fragility fracture: a secondary analysis of qualitative data.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 13 institutions in 7 countries.

V BenetouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 Mikras Asias Str, Athens, 115 27, Greece. vbenetou@med.uoa.gr.
P OrfanosDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 Mikras Asias Str, Athens, 115 27, Greece.
D FeskanichChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
K MichaëlssonDepartment of Surgical Sciences, Section of Orthopedics, Uppsala University, Uppsala, Sweden.
U Pettersson-KymmerDepartment of Pharmacology and Clinical Neurosciences and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
L A AhmedDepartment of Health and Care Sciences, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
A PeaseyDepartment of Epidemiology and Public Health, University College London, London, UK.
A WolkInstitute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden.
H BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
M BobakDepartment of Epidemiology and Public Health, University College London, London, UK.
T WilsgaardDepartment of Community Medicine, Faculty of Health Sciences, UiT-The Arctic University of Norway, Tromsø, Norway.
B SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
K-U SaumDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
A BellaviaInstitute of Environmental Medicine, Division of Nutritional Epidemiology, Karolinska Institutet, Stockholm, Sweden.
F GrodsteinChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
E KlinakiDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 Mikras Asias Str, Athens, 115 27, Greece.
E ValanouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 Mikras Asias Str, Athens, 115 27, Greece.
E-M PapatestaHellenic Health Foundation, Kaisareias 13 and Alexandroupoleos Str, Athens, 115 27, Greece.
P BoffettaHellenic Health Foundation, Kaisareias 13 and Alexandroupoleos Str, Athens, 115 27, Greece.
A TrichopoulouDepartment of Hygiene, Epidemiology and Medical Statistics, School of Medicine, University of Athens, 75 Mikras Asias Str, Athens, 115 27, Greece.
National and Kapodistrian University of Athens · GRGerman Cancer Research Center · DEHellenic Health Foundation · GRKarolinska Institutet · SEUniversity College London · GBBrigham and Women's Hospital · USHarvard University · USHeidelberg University · DEIcahn School of Medicine at Mount Sinai · USUiT The Arctic University of Norway · NOUmeå University · SEUnited Arab Emirates University · AEUppsala University · SE

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8M
NCI NIH HHS P01CA87969
6 · The paper itself

Abstract

unlabelledThe role of socioeconomic status in hip fracture incidence is unclear. In a diverse population of elderly, higher education was found to be associated with lower, whereas living alone, compared to being married/cohabiting, with higher hip fracture risk. Educational level and marital status may contribute to hip fracture risk.

introductionThe evidence on the association between socioeconomic status and hip fracture incidence is limited and inconsistent. We investigated the potential association of education and marital status with hip fracture incidence in older individuals from Europe and USA.

methodsA total of 155,940 participants (79 % women) aged 60 years and older from seven cohorts were followed up accumulating 6456 incident hip fractures. Information on education and marital status was harmonized across cohorts. Hip fractures were ascertained through telephone interviews/questionnaires or through record linkage with registries. Associations were assessed through Cox proportional hazard regression adjusting for several factors. Summary estimates were derived using random effects models.

resultsIndividuals with higher education, compared to those with low education, had lower hip fracture risk [hazard ratio (HR) = 0.84, 95 % confidence interval (CI) 0.72-0.95]. Respective HRs were 0.97 (95 % CI 0.82-1.13) for men and 0.75 (95 % CI 0.65-0.85) for women. Overall, individuals living alone, especially those aged 60-69 years, compared to those being married/cohabiting, tended to have a higher hip fracture risk (HR = 1.12, 95 % CI 1.02-1.22). There was no suggestion for heterogeneity across cohorts (P heterogeneity > 0.05).

conclusionsThe combined data from >150,000 individuals 60 years and older suggest that higher education may contribute to lower hip fracture risk. Furthermore, this risk may be higher among individuals living alone, especially among the age group 60-69 years, when compared to those being married/cohabiting.

Indexed as

Educational StatusAgedAged, 80 and overCohort StudiesEuropeFemaleHip FracturesHumansIncidenceMaleMarital StatusMiddle AgedResidence CharacteristicsRisk FactorsUnited StatesEducationElderlyFracturesHip fracturesMarital statusSocioeconomic status

Identifiers

PMID25820745
OpenAlexW2018526022

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.