ArticleEuropean journal of nuclear medicine and molecular imaging2015
Biodistribution and radiation dosimetry of (82)Rb at rest and during peak pharmacological stress in patients referred for myocardial perfusion imaging.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Consistent tracer administration profile improves test-retest repeatability of myocardial blood flow quantification withJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Trial
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- Internal dosimetry study of [European journal of nuclear medicine and molecular imaging · 2024Article
- How to assess nonresponsiveness to vasodilator stress.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Review
- Influence of Body Mass Index on Radiation Exposure Across Imaging Modalities in the Evaluation of Chest Pain.Journal of the American Heart Association · 2024Article
- Splenic switch-off in regadenosonJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Cost-effectiveness of 82-Rubidium PET myocardial perfusion imaging for the diagnosis of myocardial ischemia depending on the prevalence of coronary artery disease.EJNMMI research · 2023Article
- Rubidium-82 generator yield and efficiency for PET perfusion imaging: Comparison of two clinical systems.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Patient body motion correction for dynamic cardiac PET-CT by attenuation-emission alignment according to projection consistency conditions.Medical physics · 2019Article
- Clinical performance of Rb-82 myocardial perfusion PET and Tc-99m-based SPECT in patients with extreme obesity.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Status of cardiovascular PET radiation exposure and strategies for reduction: An Information Statement from the Cardiovascular PET Task Force.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- ASNC imaging guidelines/SNMMI procedure standard for positron emission tomography (PET) nuclear cardiology procedures.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Can PET be performed without an attenuation scan?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2016Article
- Clinical use of quantitative cardiac perfusion PET: rationale, modalities and possible indications. Position paper of the Cardiovascular Committee of the European Association of Nuclear Medicine (EANM).European journal of nuclear medicine and molecular imaging · 2016Review
- Proceedings of the ASNC Cardiac PET Summit, 12 May 2014, Baltimore, MD : 1: The value of PET: Integrating cardiovascular PET into the care continuum.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Review
- Recent Progress in PET and SPECT Myocardial Perfusion Imaging: From Radiopharmaceuticals to Imaging Innovations.Iranian journal of pharmaceutical research : IJPRReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose(82)Rb is an ultra-short-lived positron emitter used for myocardial blood flow quantification with PET imaging. The aim of this study was to quantify the biodistribution and radiation dosimetry in patients with coronary disease and in healthy normal volunteers.
methodsA total of 30 subjects, 26 patients with known or suspected coronary artery disease (CAD) and four healthy volunteers were injected with (82)Rb chloride at 10 MBq/kg followed by a 10-min dynamic PET scan. Chest scans at rest were acquired in all subjects, as well as one additional biodistribution scan of the head, neck, abdomen, pelvis or thighs. Chest scans under stress were acquired in 25 of the CAD patients. (82)Rb time-integrated activity coefficients were determined in 22 source organs using volume of interest analysis, including corrections for partial-volume losses. The mean time-integrated activity coefficients were used to calculate the whole-body effective dose using tissue weighting factors from the International Commission on Radiological Protection (ICRP) Publications 60 and 103.
resultsA total of 283 organ time-integrated activity coefficients were calculated, with a minimum of four values per source organ. The rest and stress mean effective dose was 0.8 mSv/GBq, according to the most recent ICRP definition. Using 10 MBq/kg for 3D PET imaging, the effective dose to a gender-averaged reference person (60 kg female and 73 kg male) is 1.1 mSv for a complete rest and stress perfusion study. For 2D PET using a typical injected activity of 1.1 to 2.2 GBq each for rest and stress, the effective dose for a complete study is 1.8 to 3.5 mSv.
conclusionThe current effective dose estimate in CAD patients is four times lower than the values reported previously by the ICRP, and about 35% lower than previous in vivo studies in young healthy subjects.
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