Evidence map›Paper›PMID 25820431›Full record

ArticleNucleic acids research2015

IntFOLD: an integrated server for modelling protein structures and functions from amino acid sequences.

Liam J McGuffin, Jennifer D Atkins, Bajuna R Salehe, Ahmad N Shuid, Daniel B Roche

Abstract read
In one paragraph

Article in Nucleic acids research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Quality Estimates for 3D Protein Models.Methods in molecular biology (Clifton, N.J.) · 2023
    Article
  11. Article
  12. Optimised Heterologous Expression and Functional Analysis of theInternational journal of molecular sciences · 2021
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Methods for the Refinement of Protein Structure 3D Models.International journal of molecular sciences · 2019
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liam J McGuffinSchool of Biological Sciences, University of Reading, Reading, RG6 6AS, UK l.j.mcguffin@reading.ac.uk.
Jennifer D AtkinsSchool of Biological Sciences, University of Reading, Reading, RG6 6AS, UK.
Bajuna R SaleheSchool of Biological Sciences, University of Reading, Reading, RG6 6AS, UK.
Ahmad N ShuidSchool of Biological Sciences, University of Reading, Reading, RG6 6AS, UK.
Daniel B RocheInstitut de Biologie Computationnelle, LIRMM, CNRS, Université de Montpellier, Montpellier 34095, France Centre de Recherches de Biochimie Macromoléculaire, CNRS- UMR 5237, Montpellier 34293, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntFOLD is an independent web server that integrates our leading methods for structure and function prediction. The server provides a simple unified interface that aims to make complex protein modelling data more accessible to life scientists. The server web interface is designed to be intuitive and integrates a complex set of quantitative data, so that 3D modelling results can be viewed on a single page and interpreted by non-expert modellers at a glance. The only required input to the server is an amino acid sequence for the target protein. Here we describe major performance and user interface updates to the server, which comprises an integrated pipeline of methods for: tertiary structure prediction, global and local 3D model quality assessment, disorder prediction, structural domain prediction, function prediction and modelling of protein-ligand interactions. The server has been independently validated during numerous CASP (Critical Assessment of Techniques for Protein Structure Prediction) experiments, as well as being continuously evaluated by the CAMEO (Continuous Automated Model Evaluation) project. The IntFOLD server is available at: http://www.reading.ac.uk/bioinf/IntFOLD/.

Indexed as

Models, MolecularProtein ConformationSoftwareAlgorithmsInternetLigandsProteinsProtein Structure, TertiarySequence Analysis, ProteinLigandsProteins

Identifiers

PMID25820431
PMCPMC4489238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.