ArticleAmerican journal of physiology. Heart and circulatory physiology2015
Coronary vasomotor responses to isometric handgrip exercise are primarily mediated by nitric oxide: a noninvasive MRI test of coronary endothelial function.
Article in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05711719 (Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction
Who cites it
32 citing papers in PubMed, 42 citations in OpenAlex.
- Evolocumab, a PCSK9-Monoclonal Antibody, Rapidly Reverses Coronary Artery Endothelial Dysfunction in People Living With HIV and People With Dyslipidemia.Journal of the American Heart Association · 2020Trial
- Feasibility of coronary endothelial function assessment using arterial spin labeled CMR.NMR in biomedicine · 2020Trial
- Metabolic and redox pathway dysregulation in HIV-associated coronary endothelial dysfunction.American journal of physiology. Heart and circulatory physiology · 2026Observational
- Stress and Coronary Vascular Dysfunction in Women With Prior Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Dynamic assessment of global longitudinal strain after isometric exercise to predict functionally significant coronary lesion.European heart journal. Imaging methods and practice · 2026Article
- Metabolic and Redox Pathway Dysregulation in HIV-Associated Coronary Endothelial Dysfunction: Insights into Early-Phase HIV Vascular Dysfunction.bioRxiv : the preprint server for biology · 2025Article
- Lipoprotein(a) Is Elevated and Inversely Related to Coronary Endothelial Function in People With HIV.Journal of the American Heart Association · 2024Article
- Coronary artery endothelial function and aging in people with HIV and HIV-negative individuals.American journal of physiology. Heart and circulatory physiology · 2023Article
- Effect of Sex on Coronary Endothelial Dysfunction in People Living With HIV.Journal of the American Heart Association · 2022Article
- Nitric Oxide-Mediated Coronary Endothelial Function Is Impaired in Patients With Heart Failure With Preserved Ejection Fraction.Circulation. Heart failure · 2022Article
- Imaging Assessment of Endothelial Function: An Index of Cardiovascular Health.Frontiers in cardiovascular medicine · 2022Review
- Volumetric coronary endothelial function assessment: a feasibility study exploiting stack-of-stars 3D cine MRI and image-based respiratory self-gating.NMR in biomedicine · 2021Article
- Phase contrast coronary blood velocity mapping with both high temporal and spatial resolution using triggered Golden Angle rotated Spiral k-t Sparse Parallel imaging (GASSP) with shifted binning.Magnetic resonance in medicine · 2021Article
- A Clinical Approach to Multimodality Imaging in Pulmonary Hypertension.Frontiers in cardiovascular medicine · 2021Review
- Randomized Trial of Anti-inflammatory Medications and Coronary Endothelial Dysfunction in Patients With Stable Coronary Disease.Frontiers in cardiovascular medicine · 2021Article
- The Cardiovascular Stress Response as Early Life Marker of Cardiovascular Health: Applications in Population-Based Pediatric Studies-A Narrative Review.Pediatric cardiology · 2020Review
- Noninvasive detection of impaired pulmonary artery endothelial function in people living with HIV.AIDS (London, England) · 2020Article
- Exercise cardiovascular magnetic resonance: development, current utility and future applications.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Review
- Coronary Microvascular Dysfunction in HIV: A Review.Journal of the American Heart Association · 2020Review
- Coronary vasomotion and exercise-induced adaptations in coronary artery disease patients: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Endothelial cell release of nitric oxide (NO) is a defining characteristic of nondiseased arteries, and abnormal endothelial NO release is both a marker of early atherosclerosis and a predictor of its progression and future events. Healthy coronaries respond to endothelial-dependent stressors with vasodilatation and increased coronary blood flow (CBF), but those with endothelial dysfunction respond with paradoxical vasoconstriction and reduced CBF. Recently, coronary MRI and isometric handgrip exercise (IHE) were reported to noninvasively quantify coronary endothelial function (CEF). However, it is not known whether the coronary response to IHE is actually mediated by NO and/or whether it is reproducible over weeks. To determine the contribution of NO, we studied the coronary response to IHE before and during infusion of N(G)-monomethyl-l-arginine (l-NMMA, 0.3 mg·kg(-1)·min(-1)), a NO-synthase inhibitor, in healthy volunteers. For reproducibility, we performed two MRI-IHE studies ~8 wk apart in healthy subjects and patients with coronary artery disease (CAD). Changes from rest to IHE in coronary cross-sectional area (%CSA) and diastolic CBF (%CBF) were quantified. l-NMMA completely blocked normal coronary vasodilation during IHE [%CSA, 12.9 ± 2.5 (mean ± SE, placebo) vs. -0.3 ± 1.6% (l-NMMA); P < 0.001] and significantly blunted the increase in flow [%CBF, 47.7 ± 6.4 (placebo) vs. 10.6 ± 4.6% (l-NMMA); P < 0.001]. MRI-IHE measures obtained weeks apart strongly correlated for CSA (P < 0.0001) and CBF (P < 0.01). In conclusion, the normal human coronary vasoactive response to IHE is primarily mediated by NO. This noninvasive, reproducible MRI-IHE exam of NO-mediated CEF promises to be useful for studying CAD pathogenesis in low-risk populations and for evaluating translational strategies designed to alter CAD in patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.