ArticleEuropean journal of applied physiology2015
Exercise vasodilation is greater in women: contributions of nitric oxide synthase and cyclooxygenase.
Article in European journal of applied physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Response of exercise-onset vasodilator kinetics to L-citrulline supplementation during different phases of the menstrual cycle.Physiological reports · 2020Trial
- Exercise Training in Heart Failure: Clinical Benefits and Mechanisms.Circulation research · 2025Review
- Sex differences in fatiguability during single-joint resistance exercise in a resistance-trained population.European journal of applied physiology · 2024Article
- Quadriceps fatigue during hypoxic and ischemic knee-extension exercise is similar in males and females.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Considerations for Sex-Cognizant Research in Exercise Biology and Medicine.Frontiers in sports and active living · 2022Review
- The impact of castration on physiological responses to exertional heat stroke in mice.PloS one · 2022Article
- Sex differences in muscle fatigue following isokinetic muscle contractions.Scientific reports · 2021Article
- Sleep Efficiency is Inversely Associated with Brachial Artery Diameter and Morning Blood Pressure in Midlife Adults, with a Potential Sex-Effect: A Short Comment [Letter].Nature and science of sleep · 2021Article
- Sex-related differences in rapid-onset vasodilation: impact of aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Cerebrovascular responses to graded exercise in young healthy males and females.Physiological reports · 2020Article
- Functional sympatholysis is preserved in healthy young Black men during rhythmic handgrip exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Mechanisms of sex differences in exercise capacity.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- The diagnostic value of circulating microRNAs in heart failure.Experimental and therapeutic medicine · 2019Review
- The Pulse-Respiration Quotient: A Powerful but Untapped Parameter for Modern Studies About Human Physiology and Pathophysiology.Frontiers in physiology · 2019Review
- Article
- Attenuated forearm vascular conductance responses to rhythmic handgrip in young African-American compared with Caucasian-American men.American journal of physiology. Heart and circulatory physiology · 2018Article
- Sex and nitric oxide bioavailability interact to modulate interstitial PoJournal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Phosphodiesterase-5 inhibition preserves exercise-onset vasodilator kinetics when NOS activity is reduced.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Cardiovascular Responses to Skeletal Muscle Stretching: "Stretching" the Truth or a New Exercise Paradigm for Cardiovascular Medicine?Sports medicine (Auckland, N.Z.) · 2017Review
- Post-exercise blood flow restriction attenuates hyperemia similarly in males and females.European journal of applied physiology · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe hypothesized exercise vasodilation would be greater in women due to nitric oxide synthase (NOS) and cyclooxygenase (COX) signaling.
methods45 healthy adults (23 women, W, 22 men, M, 26 ± 1 years) completed two 10-min trials of dynamic forearm exercise at 15 % intensity. Forearm blood flow (FBF; Doppler ultrasound), arterial pressure (brachial catheter), and forearm lean mass were measured to calculate relative forearm vascular conductance (FVCrel) = FBF 100 mmHg(-1) 100 g(-1) lean mass. Local intra-arterial infusion of L-NMMA or ketorolac acutely inhibited NOS and COX, respectively. In Trial 1, the first 5 min served as control exercise (CON), followed by 5 min of L-NMMA or ketorolac over the last 5 min of exercise. In Trial 2, the remaining drug was infused during 5-10 min, to achieve combined NOS-COX inhibition (double blockade, DB).
resultsAre mean ± SE. Women exhibited 29 % greater vasodilation in CON (ΔFVCrel, 19 ± 1 vs. 15 ± 1, p = 0.01). L-NMMA reduced ΔFVCrel (p < 0.001) (W: Δ -2.3 ± 1.3 vs. M: Δ -3.7 ± 0.8, p = 0.25); whereas, ketorolac modestly increased ΔFVCrel (p = 0.04) similarly between sexes (W: Δ 1.6 ± 1.1 vs. M: Δ 2.0 ± 1.6, p = 0.78). DB was also found to be similar between the sexes (p = 0.85).
conclusionThese data clearly indicate women produce a greater exercise vasodilator response. Furthermore, contrary to experiments in animal models, these data are the first to demonstrate vascular control by NOS and COX is similar between sexes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.