Evidence map›Paper›PMID 25820136›Full record

ReviewCurrent opinion in neurobiology2015

Peeling back the layers of locomotor control in the spinal cord.

David L McLean, Kimberly J Dougherty

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 80 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Excitatory Spinal Lhx9-Derived Interneurons Modulate Locomotor Frequency in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Synaptic architecture of leg and wing premotor control networks inbioRxiv : the preprint server for biology · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Recruitment of Motoneurons.Advances in neurobiology · 2022
    Article
  11. Article
  12. Developmental Exposure to Domoic Acid Disrupts Startle Response Behavior and Circuitry in Zebrafish.Toxicological sciences : an official journal of the Society of Toxicology · 2021
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Sensory cortical control of movement.Nature neuroscience · 2020
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David L McLeanDepartment of Neurobiology, Northwestern University, Evanston, IL, USA. Electronic address: david-mclean@northwestern.edu.
Kimberly J DoughertyDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: kimberly.dougherty@drexelmed.edu.
Drexel University · USNorthwestern University · US

Funding

Functional Development of Motor NetworksR01NS067299 · NINDS · NORTHWESTERN UNIVERSITY · PI MCLEAN, DAVID · 2010 to 2019
$4.0M
NINDS NIH HHS NS067299NINDS NIH HHS R01 NS067299
6 · The paper itself

Abstract

Vertebrate locomotion is executed by networks of neurons within the spinal cord. Here, we describe recent advances in our understanding of spinal locomotor control provided by work using optical and genetic approaches in mice and zebrafish. In particular, we highlight common observations that demonstrate simplification of limb and axial motor pool coordination by spinal network modularity, differences in the deployment of spinal modules at increasing speeds of locomotion, and functional hierarchies in the regulation of locomotor rhythm and pattern. We also discuss the promise of intersectional genetic strategies for better resolution of network components and connectivity, which should help us continue to close the gap between theory and function.

Indexed as

AnimalsExtremitiesHumansLocomotionModels, BiologicalMotor NeuronsNerve NetSpinal Cord

Identifiers

PMID25820136
PMCPMC4523447
OpenAlexW2013166533

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.