ArticleApplied and environmental microbiology2015
"Quorum Non-Sensing": Social Cheating and Deception in Vibrio cholerae.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Microbial metabolism in laboratory reared marine snow as revealed by a multi-omics approach.Microbiome · 2025Article
- Regulation of type VI secretion systems at the transcriptional, posttranscriptional and posttranslational level.Microbiology (Reading, England) · 2023Review
- Cell Growth Model with Stochastic Gene Expression Helps Understand the Growth Advantage of Metabolic Exchange and Auxotrophy.mSystems · 2021Article
- Quorum sensing provides a molecular mechanism for evolution to tune and maintain investment in cooperation.The ISME journal · 2021Article
- BipA exerts temperature-dependent translational control of biofilm-associated colony morphology ineLife · 2021Article
- Pathogenicity and virulence regulation ofVirulence · 2020Review
- In silico bacteria evolve robust cooperaion via complex quorum-sensing strategies.Scientific reports · 2020Article
- Role of coaggregation in the pathogenicity and prolonged colonisation of Vibrio cholerae.Medical microbiology and immunology · 2019Article
- Gluconeogenic growth of Vibrio cholerae is important for competing with host gut microbiota.Journal of medical microbiology · 2018Article
- Vibrio parahaemolyticus RhsP represents a widespread group of pro-effectors for type VI secretion systems.Nature communications · 2018Article
- Maximizing Growth Yield and Dispersal via Quorum Sensing Promotes Cooperation in Vibrio Bacteria.Applied and environmental microbiology · 2018Article
- Review
- Quorum-sensing control of antibiotic resistance stabilizes cooperation in Chromobacterium violaceum.The ISME journal · 2018Article
- A common evolutionary pathway for maintaining quorum sensing in Pseudomonas aeruginosa.Journal of microbiology (Seoul, Korea) · 2018Article
- Quorum Sensing Gene Regulation by LuxR/HapR Master Regulators in Vibrios.Journal of bacteriology · 2017Review
- Article
- Bacterial Quorum Sensing Stabilizes Cooperation by Optimizing Growth Strategies.Applied and environmental microbiology · 2016Article
- Microbial Surface Colonization and Biofilm Development in Marine Environments.Microbiology and molecular biology reviews : MMBR · 2016Review
- Facultative cheating supports the coexistence of diverse quorum-sensing alleles.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Antisocial luxO Mutants Provide a Stationary-Phase Survival Advantage in Vibrio fischeri ES114.Journal of bacteriology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Quorum sensing (QS) is widely used by bacteria to coordinate behavior in response to external stimuli. In Vibrio cholerae, this process is important for environmental survival and pathogenesis, though, intriguingly, a large percentage of natural isolates are QS deficient. Here, we show that QS-deficient mutants can spread as social cheaters by ceasing production of extracellular proteases under conditions requiring their growth. We further show that mutants stimulate biofilm formation and are over-represented in biofilms compared to planktonic communities; on this basis, we suggest that QS-deficient mutants may have the side effect of enhancing environmental tolerance of natural populations due to the inherent resistance properties of biofilms. Interestingly, high frequencies of QS-deficient individuals did not impact production of QS signaling molecules despite mutants being unable to respond to these inducers, indicating that these variants actively cheat by false signaling under conditions requiring QS. Taken together, our results suggest that social cheating may drive QS deficiency emergence within V. cholerae natural populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.