ArticleNeurogenetics2015
Long intervening non-coding RNA 00320 is human brain-specific and highly expressed in the cortical white matter.
Article in Neurogenetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Distinct regulatory functions and biological roles of lncRNA splice variants.Molecular therapy. Nucleic acids · 2023Review
- Alternative splicing of lncRNAs in human diseases.American journal of cancer research · 2021Review
- Comprehensive analysis of a long non-coding RNA-associated competing endogenous RNA network in glioma.Oncology letters · 2020Article
- Long non-coding RNA NBAT1 inhibits the progression of glioma through the miR-21/SOX7 axis.Oncology letters · 2020Article
- Long Non-coding RNA LINC00320 Inhibits Tumorigenicity of Glioma Cells and Angiogenesis Through Downregulation of NFKB1-Mediated AQP9.Frontiers in cellular neuroscience · 2020Article
- What Have Advances in Transcriptomic Technologies Taught us About Human White Matter Pathologies?Frontiers in cellular neuroscience · 2020Review
- lncRNA ROR promotes the progression of renal cell carcinoma through the miR‑206/VEGF axis.Molecular medicine reports · 2019Article
- [ARTICLE WITHDRAWN] Knockdown of Long Noncoding RNA LINC00152 Suppresses Cellular Proliferation and Invasion in Glioma Cells by Regulating miR-4775.Oncology research · 2018Article
- Microarray Expression Profile of lncRNAs and mRNAs in Rats with Traumatic Brain Injury after A2B5+ Cell Transplantation.Cell transplantation · 2017Article
- Long non-coding RNA in glioma: signaling pathways.Oncotarget · 2017Review
- Understanding the Role of lncRNAs in Nervous System Development.Advances in experimental medicine and biology · 2017Review
- LINC00507 Is Specifically Expressed in the Primate Cortex and Has Age-Dependent Expression Patterns.Journal of molecular neuroscience : MN · 2016Article
- The Antisense Transcriptome and the Human Brain.Journal of molecular neuroscience : MN · 2016Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Pervasive transcription of the genome produces a diverse array of functional non-coding RNAs (ncRNAs). One particular class of ncRNAs, long intervening non-coding RNAs (lincRNAs) are thought to play a role in regulating gene expression and may be a major contributor to organism and tissue complexity. The human brain with its heterogeneous cellular make-up is a rich source of lincRNAs; however, the functions of the majority of lincRNAs are unknown. Recently, by completing RNA sequencing (RNA-Seq) of the human frontal cortex, we identified linc00320 as being highly expressed in the white matter compared to grey matter in multiple system atrophy (MSA) brain. Here, we further investigate the expression patterns of linc00320 and conclude that it is involved in specific brain regions rather than having involvement in the MSA disease process. We also show that the full-length linc00320 is only expressed in human brain tissue and not in other primates, suggesting that it may be involved in improved functional connectivity for higher human brain cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.