Evidence map›Paper›PMID 25819861›Full record

Trial reportAmerican heart journal2015

Results of the Chronic Heart Failure Intervention to Improve MEdication Adherence study: A randomized intervention in high-risk patients.

Bradi B Granger, Inger Ekman, Adrian F Hernandez, Tenita Sawyer, Margaret T Bowers, Tracy A DeWald, Yanfang Zhao, Janet Levy, Hayden B Bosworth

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American heart journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02258516 (A Randomized Study of the Efficacy of a New Intervention for Medication Adherence in Chronic Illness), which is not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02258516 nacompletednot on this map

A Randomized Study of the Efficacy of a New Intervention for Medication Adherence in Chronic Illness: Medications, Meaning and Me (The 3-M Study)

TypeinterventionalSponsorDuke UniversityRan2009 to 2013Enrolled87ConditionsSelf-management in Heart FailureArmsCHIME 3-M, attention control
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Point-of-care tools to support optometric care provision to people with age-related macular degeneration: A randomised, placebo-controlled trial.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2022
    Trial
  5. Effectiveness of personalised support for self-management in primary care: a cluster randomised controlled trial.The British journal of general practice : the journal of the Royal College of General Practitioners · 2016
    Trial
  6. Article
  7. Article
  8. Review
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  10. Review
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  12. Observational
  13. Article
  14. Article
  15. Use of Digital Health Technology in Heart Failure and Diabetes: a Scoping Review.Journal of cardiovascular translational research · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Bradi B GrangerDuke University School of Nursing, Durham, NC; Duke University Health Systems, Durham, NC. Electronic address: bradi.granger@dm.duke.edu.
Inger EkmanInstitute of Health and Care Sciences, Centre for Person-Centred Care, University of Gothenburg, Göteborg, Sweden.
Adrian F HernandezDuke Clinical Research Institute, Duke Medicine, Durham, NC.
Tenita SawyerDuke University Health Systems, Durham, NC.
Margaret T BowersDuke University School of Nursing, Durham, NC; Duke University Health Systems, Durham, NC.
Tracy A DeWaldDuke University Health Systems, Durham, NC.
Yanfang ZhaoSAS Institute, Cary, NC.
Janet LevyDuke University School of Nursing, Durham, NC.
Hayden B BosworthCenter for Health Services Research in Primary Care, VA Medical Center, Durham, NC.
Duke University · USDuke University Health System · USClinical Research Institute · USSAS Institute (United States) · USUniversity of Gothenburg · SE

Funding

A Randomized, Controlled Pilot Study of an Intervention for Medication AdherenceR03NR011500 · NINR · DUKE UNIVERSITY · PI GRANGER, BRADI B. · 2009 to 2010
$155k
NINR NIH HHS 5R03-NR-011500-02NINR NIH HHS R03 NR011500
6 · The paper itself

Abstract

backgroundPoor adherence to evidence-based medications in heart failure (HF) is a major cause of avoidable hospitalizations, disability, and death. To test the feasibility of improving medication adherence, we performed a randomized proof-of-concept study of a self-management intervention in high-risk patients with HF.

methodsPatients with HF who screened positively for poor adherence (<6 Morisky Medication Adherence Scale 8-item) were randomized to either the intervention or attention control group. In the intervention group (n = 44), a nurse conducted self-management training before discharge that focused on identification of medication goals, facilitation of medication-symptom associations, and use of a symptom response plan. The attention control group (n = 42) received usual care; both groups received follow-up calls at 1 week. However, the content of follow-up calls for the attention control group was unrelated to HF medications or symptoms. General linear mixed models were used to evaluate the magnitude of change in adherence and symptom-related events at 3-, 6-, and 12-month follow-up clinic visits. Efficacy was measured as improved medication adherence using nurse-assessed pill counts at each time point.

resultsPooled over all time points, patients in the intervention group were more likely to be adherent to medications compared with patients in the attention control group (odds ratio 3.92, t = 3.51, P = .0007).

conclusionsA nurse-delivered, self-care intervention improved medication adherence in patients with advanced HF. Further work is needed to examine whether this intervention can be sustained to improve clinical outcomes.

Indexed as

Medication AdherenceCardiovascular AgentsFemaleFollow-Up StudiesHeart FailureHospitalizationHumansMaleMiddle AgedPrognosisProspective StudiesRisk FactorsSelf CareSurvival RateUnited StatesCardiovascular Agents

Identifiers

PMID25819861
PMCPMC5058442
OpenAlexW1993479123

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.