ArticleBiology open2015
Bridging the gap between postembryonic cell lineages and identified embryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster.
Article in Biology open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Inhibitory circuits control leg movements duringeLife · 2026Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
- A cell atlas of the larval Aedes aegypti ventral nerve cord.Neural development · 2024Article
- Differential adhesion during development establishes individual neural stem cell niches and shapes adult behaviour in Drosophila.PLoS biology · 2023Article
- IntacteLife · 2022Article
- Integrated Patterning Programs DuringAnnual review of neuroscience · 2021Article
- Article
- Central processing of leg proprioception ineLife · 2020Article
- A single-cell transcriptomic atlas of the adulteLife · 2020Article
- Nucleolar stress inBiology open · 2020Article
- Identification of Neuronal Lineages in the Drosophila Peripheral Nervous System with a "Digital" Multi-spectral Lineage Tracing System.Cell reports · 2019Article
- Decoupling developmental apoptosis and neuroblast proliferation in Drosophila.Developmental biology · 2019Article
- Review
- Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.eLife · 2019Article
- The development and assembly of the Drosophila adult ventral nerve cord.Current opinion in neurobiology · 2019Review
- Article
- Drosophila as a Model for Developmental Biology: Stem Cell-Fate Decisions in the Developing Nervous System.Journal of developmental biology · 2018Review
- Progressive derivation of serially homologous neuroblast lineages in the gnathal CNS of Drosophila.PloS one · 2018Article
- Structure and development of the subesophageal zone of the Drosophila brain. I. Segmental architecture, compartmentalization, and lineage anatomy.The Journal of comparative neurology · 2018Article
- Combinatorial action of Grainyhead, Extradenticle and Notch in regulating Hox mediated apoptosis in Drosophila larval CNS.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The clarification of complete cell lineages, which are produced by specific stem cells, is fundamental for understanding mechanisms, controlling the generation of cell diversity and patterning in an emerging tissue. In the developing Central Nervous System (CNS) of Drosophila, neural stem cells (neuroblasts) exhibit two periods of proliferation: During embryogenesis they produce primary lineages, which form the larval CNS. After a phase of mitotic quiescence, a subpopulation of them resumes proliferation in the larva to give rise to secondary lineages that build up the CNS of the adult fly. Within the ventral nerve cord (VNC) detailed descriptions exist for both primary and secondary lineages. However, while primary lineages have been linked to identified neuroblasts, the assignment of secondary lineages has so far been hampered by technical limitations. Therefore, primary and secondary neural lineages co-existed as isolated model systems. Here we provide the missing link between the two systems for all lineages in the thoracic and abdominal neuromeres. Using the Flybow technique, embryonic neuroblasts were identified by their characteristic and unique lineages in the living embryo and their further development was traced into the late larval stage. This comprehensive analysis provides the first complete view of which embryonic neuroblasts are postembryonically reactivated along the anterior/posterior-axis of the VNC, and reveals the relationship between projection patterns of primary and secondary sublineages.
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Registered trials
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