ArticleEnvironmental research2015
Longitudinal measures of perfluoroalkyl substances (PFAS) in serum of Gullah African Americans in South Carolina: 2003-2013.
Article in Environmental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Review
- Article
- PFAS levels in paired drinking water and serum samples collected from an exposed community in Central North Carolina.The Science of the total environment · 2023Article
- Firefighters' exposure to per-and polyfluoroalkyl substances (PFAS) as an occupational hazard: A review.Frontiers in materials · 2023Article
- Serum concentrations of legacy and emerging per- and polyfluoroalkyl substances in the Anniston Community Health Surveys (ACHS I and ACHS II).Environment international · 2022Article
- Increased toxicity and retention of perflourooctane sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a high-fat diet (HFD).Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Article
- Per- and Polyfluoroalkyl Substances in Human Serum Samples of Selected Populations from Ghana.International journal of environmental research and public health · 2021Article
- 20th Pollutant Responses in Marine Organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms.Aquatic toxicology (Amsterdam, Netherlands) · 2020Article
- Risk to human health related to the presence of perfluoroalkyl substances in food.EFSA journal. European Food Safety Authority · 2020Article
- Temporal trends and determinants of serum concentrations of per- and polyfluoroalkyl substances among Northern California mothers with a young child, 2009-2016.Environmental research · 2020Article
- Temporal Trends in Per- and Polyfluoroalkyl Substances in Bottlenose Dolphins (Environmental science & technology · 2019Article
- Physico-chemical properties and gestational diabetes predict transplacental transfer and partitioning of perfluoroalkyl substances.Environment international · 2019Article
- Tap Water Contributions to Plasma Concentrations of Poly- and Perfluoroalkyl Substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women.Environmental health perspectives · 2019Article
- Online Serum PFOA Calculator for Adults.Environmental health perspectives · 2017Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundCharleston Harbor has elevated concentrations of PFAS in dolphins, but local human exposure data are limited.
objectivesWe sought to describe PFAS serum concentrations' temporal trends among Gullah African American residents of coastal South Carolina.
methodsLongitudinal measures of PFAS in blood serum from a Gullah clinical sample, without lupus, were examined using spaghetti plots and visit-to-visit change scores (e.g., differences in concentrations between visits) among the 68 participants with repeated measures available. We also modeled population-level trends among the 71 participants with any data using proportionate percentile models, accounting for clustering through robust standard errors. In a post-hoc analysis we examined heterogeneity of temporal trends by age through mixed-effects models for the log-transformed PFAS compounds.
resultsPopulation concentrations of PFOS dropped approximately 9 (95% CI: 8, 10) percent each year over 2003-2013. This was concordant with individual PFOS trajectories (median PFOS change score -21.7 ng/g wet weight, interquartile range of PFOS change scores: -32.8, -14.9) and reports for other populations over this time period. Several other compounds including PFOA, PFHxS, and PFuNDA also showed a population-level decrease. However, examination of individual trajectories suggested substantial heterogeneity. Post-hoc analyses indicated that PFAS trajectories were heterogeneous by age.
conclusionsMany PFAS compounds are decreasing in a sample of Gullah African Americans from coastal South Carolina. There may be age differences in the elimination kinetics of PFASs. The possible role of age as a modifier of PFAS serum trends merits further research.
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