ReviewExperimental eye research2015
From nano to macro: studying the hierarchical structure of the corneal extracellular matrix.
Review in Experimental eye research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- Nanoscale biomechanical remodeling in human myopic corneal lenticule revealed by quantitative dynamic AFM.Biophysical reports · 2026Article
- Proteomic analysis reveals key differences in pro-stromal corneal tissue between highly myopic males and females.Frontiers in medicine · 2024Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- A review of the epithelial and stromal effects of corneal collagen crosslinking.The ocular surface · 2023Review
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Noncontact Acoustic Micro-Tapping Optical Coherence Elastography for Quantification of Corneal Anisotropic Elasticity: In Vivo Rabbit Study.Translational vision science & technology · 2023Article
- Article
- Biomechanics of keratoconus: Two numerical studies.PloS one · 2023Article
- A proposed model of xeno-keratoplasty using 3D printing and decellularization.Frontiers in pharmacology · 2023Article
- Effectiveness of collagen cross-linking induced by two-photon absorption properties of a femtosecond laser inBiomedical optics express · 2022Article
- A Workflow for Three-Dimensional Reconstruction and Quantification of the Monkey Optic Nerve Head Vascular Network.Journal of biomechanical engineering · 2022Article
- Real-time imaging of optic nerve head collagen microstructure and biomechanics using instant polarized light microscopy.Experimental eye research · 2022Article
- Finite element modeling of the complex anisotropic mechanical behavior of the human sclera and pia mater.Computer methods and programs in biomedicine · 2022Article
- Polarized photoacoustic microscopy based on high-order harmonics for anisotropy detection.Annals of translational medicine · 2022Article
- The Effect of ChromaGen Contact Lenses on Corneal Clarity: A Corneal Densitometry.Beyoglu eye journal · 2022Article
- Quantitative structural imaging of keratoconic corneas using polarization-resolved SHG microscopy.Biomedical optics express · 2021Article
- The effect of intraocular pressure elevation and related ocular biometry changes on corneal OCT speckle distribution in porcine eyes.PloS one · 2021Article
- Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT.Biomedical optics express · 2020Article
- Composition, structure and function of the corneal stroma.Experimental eye research · 2020Review
- Nearly-incompressible transverse isotropy (NITI) of cornea elasticity: model and experiments with acoustic micro-tapping OCE.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In this review, we discuss current methods for studying ocular extracellular matrix (ECM) assembly from the 'nano' to the 'macro' levels of hierarchical organization. Since collagen is the major structural protein in the eye, providing mechanical strength and controlling ocular shape, the methods presented focus on understanding the molecular assembly of collagen at the nanometre level using X-ray scattering through to the millimetre to centimetre level using non-linear optical (NLO) imaging of second harmonic generated (SHG) signals. Three-dimensional analysis of ECM structure is also discussed, including electron tomography, serial block face scanning electron microscopy (SBF-SEM) and digital image reconstruction. Techniques to detect non-collagenous structural components of the ECM are also presented, and these include immunoelectron microscopy and staining with cationic dyes. Together, these various approaches are providing new insights into the structural blueprint of the ocular ECM, and in particular that of the cornea, which impacts upon our current understanding of the control of corneal shape, pathogenic mechanisms underlying ectatic disorders of the cornea and the potential for corneal tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.