Evidence map›Paper›PMID 25819276›Full record

ReviewAdvances in protein chemistry and structural biology2015

Modifications of natural peptides for nanoparticle and drug design.

Andrew P Jallouk, Rohun U Palekar, Hua Pan, Paul H Schlesinger, Samuel A Wickline

Abstract readReview
In one paragraph

Review in Advances in protein chemistry and structural biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Peptides for trans-blood-brain barrier delivery.Journal of labelled compounds & radiopharmaceuticals · 2023
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew P JalloukConsortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Rohun U PalekarConsortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Hua PanConsortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Paul H SchlesingerDepartment of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Samuel A WicklineConsortium for Translational Research in Advanced Imaging and Nanomedicine, Department of Medicine, Division of Cardiology, Washington University in St. Louis, St. Louis, Missouri, USA; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA. Electronic address: wicklines@aol.com.

Funding

METHODS IN MOLECULAR IMAGING AND TARGETED THERAPEUTICSR01HL073646 · NHLBI · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2004 to 2016
$13.7M
Translational Research Skills Development CoreU54HL112303 · NHLBI · WASHINGTON UNIVERSITY · PI SADLER, J EVAN · 2012 to 2016
$8.8M
Prevention and Treatment of Acute Kidney InjuryR01DK102691 · NIDDK · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2015 to 2018
$2.0M
Inhibition of NF-kB with siRNA/Peptide Nanoparticles for Arthritis TreatmentR01AR067491 · NIAMS · WASHINGTON UNIVERSITY · PI PHAM, CHRISTINE T., WICKLINE, SAMUEL A · 2015 to 2019
$1.8M
THERAPY NANOPARTICLES FOR MODULATION OF INFLAMMATION IN NEUROMUSCULAR DISEASER01AR056223 · NIAMS · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2009 to 2013
$1.6M
QUANTIFYING KIDNEY INJURY AND INFLAMMATION WITH FLUORINE (19F) MRIR21DK095555 · NIDDK · WASHINGTON UNIVERSITY · PI WICKLINE, SAMUEL A · 2012 to 2013
$411k
NHLBI NIH HHS R01 HL073646NHLBI NIH HHS U54 HL112303NIAMS NIH HHS R01 AR056223NIAMS NIH HHS R01 AR067491NIDDK NIH HHS R01 DK102691NIDDK NIH HHS R21 DK095555
6 · The paper itself

Abstract

Natural products serve as an important source of novel compounds for drug development. Recently, peptides have emerged as a new class of therapeutic agents due to their versatility and specificity for biological targets. Yet, their effective application often requires use of a nanoparticle delivery system. In this chapter, we review the role of natural peptides in the design and creation of nanomedicines, with a particular focus on cell-penetrating peptides, antimicrobial peptides, and peptide toxins. The use of natural peptides in conjunction with nanoparticle delivery systems holds great promise for the development of new therapeutic formulations as well as novel platforms for the delivery of various cargoes.

Indexed as

Drug DesignAmino Acid SequenceAnimalsBiological ProductsCell-Penetrating PeptidesDrug Delivery SystemsHumansMolecular Sequence DataNanoparticlesToxins, BiologicalBiological ProductsCell-Penetrating PeptidesToxins, BiologicalAntimicrobial peptideCell-penetrating peptideDrug deliveryNanoparticleNatural peptidePeptide toxin

Identifiers

PMID25819276
PMCPMC4750874

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.