ArticleNature communications2015
The ancestral role of nodal signalling in breaking L/R symmetry in the vertebrate forebrain.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Article
- Enigmatic Nodal and Lefty gene repertoire discrepancy: Latent evolutionary history revealed by vertebrate-wide phylogeny.Developmental dynamics : an official publication of the American Association of Anatomists · 2025Review
- Postembryonic Maintenance of Nephron Progenitor Cells with Low Translational Activity in the Chondrichthyan Scyliorhinus canicula.Journal of the American Society of Nephrology : JASN · 2025Article
- The lamprey habenula provides an extreme example for the temporal regulation of asymmetric development.Frontiers in cell and developmental biology · 2025Article
- The Sensory Shark: High-quality Morphological, Genomic and Transcriptomic Data for the Small-spotted Catshark Scyliorhinus Canicula Reveal the Molecular Bases of Sensory Organ Evolution in Jawed Vertebrates.Molecular biology and evolution · 2024Article
- Analysis of a shark reveals ancient, Wnt-dependent, habenular asymmetries in vertebrates.Nature communications · 2024Article
- Distribution of Brain-Derived Neurotrophic Factor in the Brain of the Small-Spotted CatsharkInternational journal of molecular sciences · 2023Article
- Left-right asymmetric expression of theFrontiers in cell and developmental biology · 2022Article
- Diversification of habenular organization and asymmetries in teleosts: Insights from the Atlantic salmon and European eel.Frontiers in cell and developmental biology · 2022Article
- Developmental genoarchitectonics as a key tool to interpret the mature anatomy of the chondrichthyan hypothalamus according to the prosomeric model.Frontiers in neuroanatomy · 2022Article
- When Bigger Is Better: 3D RNA Profiling of the Developing Head in the CatsharkFrontiers in cell and developmental biology · 2021Article
- Article
- Comparison of village dog and wolf genomes highlights the role of the neural crest in dog domestication.BMC biology · 2018Article
- Development and connectivity of the habenular nuclei.Seminars in cell & developmental biology · 2018Review
- Neurogenetic asymmetries in the catshark developing habenulae: mechanistic and evolutionary implications.Scientific reports · 2018Article
- Asymmetric pitx2 expression in medaka epithalamus is regulated by nodal signaling through an intronic enhancer.Development genes and evolution · 2018Article
- The Shark Basal Hypothalamus: Molecular Prosomeric Subdivisions and Evolutionary Trends.Frontiers in neuroanatomy · 2018Article
- Heterotaxy in Caenorhabditis: widespread natural variation in left-right arrangement of the major organs.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Nodal signalling and asymmetry of the nervous system.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Cellular and Molecular Features of Developmentally Programmed Genome Rearrangement in a Vertebrate (Sea Lamprey: Petromyzon marinus).PLoS genetics · 2016Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left-right asymmetries in the epithalamic region of the brain are widespread across vertebrates, but their magnitude and laterality varies among species. Whether these differences reflect independent origins of forebrain asymmetries or taxa-specific diversifications of an ancient vertebrate feature remains unknown. Here we show that the catshark Scyliorhinus canicula and the lampreys Petromyzon marinus and Lampetra planeri exhibit conserved molecular asymmetries between the left and right developing habenulae. Long-term pharmacological treatments in these species show that nodal signalling is essential to their generation, rather than their directionality as in teleosts. Moreover, in contrast to zebrafish, habenular left-right differences are observed in the absence of overt asymmetry of the adjacent pineal field. These data support an ancient origin of epithalamic asymmetry, and suggest that a nodal-dependent asymmetry programme operated in the forebrain of ancestral vertebrates before evolving into a variable trait in bony fish.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.