Evidence map›Paper›PMID 25818989›Full record

ArticleScientific reports2015

In-line phase-contrast and grating-based phase-contrast synchrotron imaging study of brain micrometastasis of breast cancer.

Sheng Huang, Binquan Kou, Yayun Chi, Yan Xi, Yixin Cao, Wenli Cui, Xin Hu, Zhimin Shao, Han Guo, Yanan Fu and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  4. In situ phase contrast X-ray brain CT.Scientific reports · 2018
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  7. Interior Tomography from Differential Phase Contrast Data via Hilbert Transform Based on Spline Functions.Proceedings of SPIE--the International Society for Optical Engineering · 2016
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Sheng HuangDepartment of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Binquan KouDepartment of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yayun ChiDepartment of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Yan Xi1] School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China [2] Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yixin CaoDepartment of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Wenli Cui1] Department of Pathology, Fudan University, Shanghai Cancer Center, Shanghai, People's Republic of China [2] Department of Pathology, First Affiliated Hospital Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region, People's Republic of China.
Xin HuDepartment of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Zhimin ShaoDepartment of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Han GuoShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Yanan FuShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Tiqiao XiaoShanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Jianqi SunSchool of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Jun Zhao1] School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China [2] Med-X Research Institute, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Yujie WangDepartment of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Jiong WuDepartment of Breast Surgery, Breast Cancer Institute, Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, People's Republic of China.
Fudan University Shanghai Cancer Center · CNShanghai Jiao Tong University · CNShanghai Institute of Applied Physics · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current bio-medical imaging researches aim to detect brain micrometastasis in early stage for its increasing incidence and high mortality rates. Synchrotron phase-contrast imaging techniques, such as in-line phase-contrast (IPC) and grating-based phase-contrast (GPC) imaging, could provide a high spatial and density imaging study of biological specimens' 3D structures. In this study, we demonstrated the detection efficiencies of these two imaging tools on breast cancer micrometastasis in an ex vivo mouse brain. We found that both IPC and GPC can differentiate abnormal brain structures induced by micrometastasis from the surrounding normal tissues. We also found that GPC was more sensitive in detecting the small metastasis as compared to IPC.

Indexed as

Diagnostic ImagingAnimalsBrain NeoplasmsBreast NeoplasmsContrast MediaFemaleHumansMiceNeoplasm MicrometastasisRadiographySynchrotronsContrast Media

Identifiers

PMID25818989
PMCPMC4377630
OpenAlexW2094329328

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.