Evidence map›Paper›PMID 25818868›Full record

ArticleBrain : a journal of neurology2015

An ImmunoChip study of multiple sclerosis risk in African Americans.

Noriko Isobe, Lohith Madireddy, Pouya Khankhanian, Takuya Matsushita, Stacy J Caillier, Jayaji M Moré, Pierre-Antoine Gourraud, Jacob L McCauley, Ashley H Beecham, International Multiple Sclerosis Genetics Consortium and 12 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain : a journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Multiple sclerosis: molecular pathogenesis and therapeutic intervention.Signal transduction and targeted therapy · 2025
    Review
  5. Is DEXI a Multiple Sclerosis Susceptibility Gene?International journal of molecular sciences · 2025
    Review
  6. Article
  7. GWAS highlights the neuronal contribution to multiple sclerosis susceptibility.medRxiv : the preprint server for health sciences · 2024
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. TheIranian journal of biotechnology · 2022
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Noriko Isobe1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA 2 Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Saga 849-8501, Japan.
Lohith Madireddy1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Pouya Khankhanian1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Takuya Matsushita1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA 3 Department of Neurological Therapeutics, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812-8582, Japan.
Stacy J Caillier1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Jayaji M Moré1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Pierre-Antoine Gourraud1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Jacob L McCauley4 John P. Hussman Institute for Human Genomics and The Dr John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
Ashley H Beecham4 John P. Hussman Institute for Human Genomics and The Dr John T Macdonald Foundation Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
International Multiple Sclerosis Genetics Consortium
Laura Piccio5 Department of Neurology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Joseph Herbert6 Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.
Omar Khan7 Multiple Sclerosis Centre and The Sastry Foundation Advanced Imaging Laboratory, Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Jeffrey Cohen8 Mellen Centre for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Lael Stone8 Mellen Centre for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Adam Santaniello1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Bruce A C Cree1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Suna Onengut-Gumuscu9 Centre for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Stephen S Rich9 Centre for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Stephen L Hauser1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA.
Stephen Sawcer10 Department of Clinical Neurosciences, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK.
Jorge R Oksenberg1 Department of Neurology, School of Medicine, University of California, San Francisco, CA 94158, USA Jorge.Oksenberg@ucsf.edu.
University of California, San Francisco · USKyushu University · JPWashington University in St. Louis · US

Funding

Type 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8M
A Haplotype Map for Multiple SclerosisR01NS049477 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAUSER, STEPHEN L · 2005 to 2014
$15.3M
Gene Expression and Regulatory Networks in Human LeukocytesRC2GM093080 · NIGMS · HARVARD MEDICAL SCHOOL · PI BENOIST, CHRISTOPHE O., MATHIS, DIANE J · 2009 to 2010
$7.3M
Immunogenetic Studies in Multiple SclerosisR01NS046297 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKSENBERG, JORGE R. · 2003 to 2013
$3.5M
The contribution of common and rare variants to autoimmunity in African AmericansR01NS076492 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI OKSENBERG, JORGE R. · 2011 to 2014
$1.3M
NIDDK NIH HHS U01 DK062418NIGMS NIH HHS RC2 GM093080NINDS NIH HHS R01 NS046297NINDS NIH HHS R01NS046297NINDS NIH HHS R01 NS049477NINDS NIH HHS R01NS049477NINDS NIH HHS R01 NS076492NINDS NIH HHS R01NS076492Wellcome Trust
6 · The paper itself

Abstract

The aims of this study were: (i) to determine to what degree multiple sclerosis-associated loci discovered in European populations also influence susceptibility in African Americans; (ii) to assess the extent to which the unique linkage disequilibrium patterns in African Americans can contribute to localizing the functionally relevant regions or genes; and (iii) to search for novel African American multiple sclerosis-associated loci. Using the ImmunoChip custom array we genotyped 803 African American cases with multiple sclerosis and 1516 African American control subjects at 130 135 autosomal single nucleotide polymorphisms. We conducted association analysis with rigorous adjustments for population stratification and admixture. Of the 110 non-major histocompatibility complex multiple sclerosis-associated variants identified in Europeans, 96 passed stringent quality control in our African American data set and of these, >70% (69) showed over-representation of the same allele amongst cases, including 21 with nominally significant evidence for association (one-tailed test P < 0.05). At a further eight loci we found nominally significant association with an alternate correlated risk-tagging single nucleotide polymorphism from the same region. Outside the regions known to be associated in Europeans, we found seven potentially associated novel candidate multiple sclerosis variants (P < 10(-4)), one of which (rs2702180) also showed nominally significant evidence for association (one-tailed test P = 0.034) in an independent second cohort of 620 African American cases and 1565 control subjects. However, none of these novel associations reached genome-wide significance (combined P = 6.3 × 10(-5)). Our data demonstrate substantial overlap between African American and European multiple sclerosis variants, indicating common genetic contributions to multiple sclerosis risk.

Indexed as

Oligonucleotide Array Sequence AnalysisAllelesBlack or African AmericanCase-Control StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMultiple SclerosisPolymorphism, Single NucleotideAfrican AmericansImmunoChiplinkage disequilibriummultiple sclerosis

Identifiers

PMID25818868
PMCPMC4553906
OpenAlexW1981016924

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.