Evidence map›Paper›PMID 25818864›Full record

ReviewTrends in immunology2015

Codification of bidentate pMHC interaction with TCR and its co-receptor.

Ellis L Reinherz, Jia-huai Wang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. T cell antigen discovery.Nature methods · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ellis L ReinherzLaboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: ellis_reinherz@dfci.harvard.edu.
Jia-huai WangLaboratory of Immunobiology and Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Dana-Farber Cancer Institute · USHarvard University Press · US

Funding

Crossprotective CTL Against InfluenzaU01AI090043 · NIAID · DANA-FARBER CANCER INST · PI REINHERZ, ELLIS L · 2010 to 2015
$6.4M
T CELL ANTIGEN RECOGNITIONR37AI019807 · NIAID · DANA-FARBER CANCER INSTITUTE · PI REINHERZ, ELLIS L · 1999 to 2008
$4.4M
T Cell Antigen RecognitionR01AI019807 · NIAID · DANA-FARBER CANCER INSTITUTE · PI REINHERZ, ELLIS L · 1985 to 2010
$1.3M
T Cell Antigen RecognitionR56AI019807 · NIAID · DANA-FARBER CANCER INST · PI REINHERZ, ELLIS L · 2012 to 2012
$430k
NIAID NIH HHS R01 AI019807NIAID NIH HHS R37 AI019807NIAID NIH HHS R56 AI019807NIAID NIH HHS U01 AI090043
6 · The paper itself

Abstract

A 1983 Immunology Today rostrum hypothesized that each T cell has two recognition units: a T cell receptor (TCR) complex, which binds antigen associated with a polymorphic region of a MHC molecule (pMHC), and a CD4 or CD8 molecule that binds to a conserved region of that same MHC gene product (class II or I, respectively). Structural biology has since precisely revealed those bidentate pMHC interactions. TCRαβ ligates the membrane-distal antigen-binding MHC platform, whereas CD8 clamps a membrane-proximal MHCI α3 domain loop and CD4 docks to a hydrophobic crevice between MHCII α2 and β2 domains. Here, we review how MHC class-restricted binding impacts signaling and lineage commitment, discussing TCR force-driven conformational transitions that may optimally expose the co-receptor docking site on MHC.

Indexed as

AnimalsHistocompatibility AntigensHumansMajor Histocompatibility ComplexModels, BiologicalModels, MolecularProtein BindingProtein ConformationProtein Interaction Domains and MotifsProtein MultimerizationReceptors, Antigen, T-CellT-LymphocytesHistocompatibility AntigensReceptors, Antigen, T-Cellantigen recognitionco-receptormechanobiologyTCR

Identifiers

PMID25818864
PMCPMC4420642
OpenAlexW1990109380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.