ArticlePlant physiology2015
The barley Uniculme4 gene encodes a BLADE-ON-PETIOLE-like protein that controls tillering and leaf patterning.
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Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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57citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Meta-QTL and ortho-MQTL analyses identified genomic regions controlling rice yield, yield-related traits and root architecture under water deficit conditions.Scientific reports · 2021Pooled it
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- Heat and Drought Co-Stress During Microgametogenesis Altered Pollen Development, Fertility and Grain Production in Two-Rowed Winter Barley.Plants (Basel, Switzerland) · 2026Article
- Cell fate acquisition at a de novo developmental boundary in the maize leaf.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The C2H2 Zinc-Finger protein ELR1 negatively regulates cytokinin metabolism and signaling pathway in rice.Functional & integrative genomics · 2025Article
- Unlocking grass leaf development: foundations for tunable cereal design.The New phytologist · 2025Review
- Fine-mapping theMolecular breeding : new strategies in plant improvement · 2025Article
- Pleiotropic effects of barley BLADE-ON-PETIOLE gene Uniculme4 on plant architecture and the jasmonic acid pathway.Journal of experimental botany · 2025Article
- The selection and application of tiller number QTLs in modern wheat breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Identification and validation of a novel tiller inhibition locus (Molecular breeding : new strategies in plant improvement · 2025Article
- Hordeum I genome unlocks adaptive evolution and genetic potential for crop improvement.Nature plants · 2025Article
- Altered interactions between cis-regulatory elements partially resolve BLADE-ON-PETIOLE genetic redundancy in Capsella rubella.The Plant cell · 2024Article
- A guide to barley mutants.Hereditas · 2024Review
- Genome-wide screening of meta-QTL and candidate genes controlling yield and yield-related traits in barley (Hordeum vulgare L.).PloS one · 2024Article
- A BLADE-ON-PETIOLE orthologue regulates corolla differentiation in the proximal region in Torenia fournieri.Nature communications · 2023Article
- Article
- Identification and high-resolution mapping of a novel tiller number gene (tin6) by combining forward genetics screen and MutMap approach in bread wheat.Functional & integrative genomics · 2023Article
- The Secrets of Meristems Initiation: Axillary Meristem Initiation and Floral Meristem Initiation.Plants (Basel, Switzerland) · 2023Review
- Anisotropic cell growth at the leaf base promotes age-related changes in leaf shape in Arabidopsis thaliana.The Plant cell · 2023Article
- Regulation of secondary growth by poplarFrontiers in plant science · 2023Article
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Authors and funding
17 authors at 4 institutions in 5 countries.
Elahe TavakolUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Ron OkagakiUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Gabriele VerderioUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Vahid Shariati JUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Ahmed HussienUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Hatice BilgicUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Mike J ScanlonUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Natalie R TodtUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Timothy J CloseUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Arnis DrukaUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Robbie WaughUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Burkhard SteuernagelUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Ruvini AriyadasaUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Axel HimmelbachUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Nils SteinUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.).
Gary J MuehlbauerUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.) laura.rossini@unimi.it muehl003@umn.edu.
Laura RossiniUniversità degli Studi di Milano, Dipartimento di Scienze Agrarie e Ambientali-Produzione, Territorio, Agroenergia, 20133 Milan, Italy (E.T., G.V., A.Hu., L.R.);Department of Crop Production and Plant Breeding, College of Agriculture, Shiraz University, Shiraz, Iran (E.T.);Department of Agronomy and Plant Genetics (R.O., H.B., G.J.M.) and Department of Plant Biology (G.J.M.), University of Minnesota, St. Paul, Minnesota 55108;Parco Tecnologico Padano, 26900 Lodi, Italy (V.S.J., L.R.);Department of Plant Biology, Cornell University, Ithaca, New York 14853 (M.J.S., N.R.T.);Department of Botany and Plant Sciences, University of California, Riverside, California 92521-0124 (T.J.C.);James Hutton Institute, Invergowrie, Dundee DD2 5DA, United Kingdom (A.D., R.W.); andLeibniz Institute of Plant Genetics and Crop Plant Research, 06466 Stadt Seeland, Germany (B.S., R.A., A.Hi., N.S.) laura.rossini@unimi.it muehl003@umn.edu.ORCID http://orcid.org/0000-0001-6509-9177
University of Milan · ITJames Hutton Institute · GBUniversity of California, Riverside · USUniversity of Minnesota · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tillers are vegetative branches that develop from axillary buds located in the leaf axils at the base of many grasses. Genetic manipulation of tillering is a major objective in breeding for improved cereal yields and competition with weeds. Despite this, very little is known about the molecular genetic bases of tiller development in important Triticeae crops such as barley (Hordeum vulgare) and wheat (Triticum aestivum). Recessive mutations at the barley Uniculme4 (Cul4) locus cause reduced tillering, deregulation of the number of axillary buds in an axil, and alterations in leaf proximal-distal patterning. We isolated the Cul4 gene by positional cloning and showed that it encodes a BROAD-COMPLEX, TRAMTRACK, BRIC-À-BRAC-ankyrin protein closely related to Arabidopsis (Arabidopsis thaliana) BLADE-ON-PETIOLE1 (BOP1) and BOP2. Morphological, histological, and in situ RNA expression analyses indicate that Cul4 acts at axil and leaf boundary regions to control axillary bud differentiation as well as the development of the ligule, which separates the distal blade and proximal sheath of the leaf. As, to our knowledge, the first functionally characterized BOP gene in monocots, Cul4 suggests the partial conservation of BOP gene function between dicots and monocots, while phylogenetic analyses highlight distinct evolutionary patterns in the two lineages.
Indexed as
Body PatterningGenes, PlantAnkyrinsArabidopsisArabidopsis ProteinsCloning, MolecularFlowersHordeumMolecular Sequence DataMutationPhenotypePlant LeavesPlant ProteinsPlant ShootsAnkyrinsArabidopsis ProteinsPlant Proteins
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