Evidence map›Paper›PMID 25818420›Full record

ArticleBiomaterials2015

3D surface topology guides stem cell adhesion and differentiation.

Priyalakshmi Viswanathan, Matthew G Ondeck, Somyot Chirasatitsin, Kamolchanok Ngamkham, Gwendolen C Reilly, Adam J Engler, Giuseppe Battaglia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 198 citations in OpenAlex.

  1. Review
  2. Article
  3. Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Standardised Matrices for Stem Cells.Advances in experimental medicine and biology · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Priyalakshmi ViswanathanKrebs Institute, The University of Sheffield, Sheffield S10 2TN, UK; Department of Biomedical Sciences, The University of Sheffield, Sheffield S10 2TN, UK.
Matthew G OndeckSanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Material Science Program, University of California, San Diego, La Jolla, CA 92093, USA.
Somyot ChirasatitsinDepartment of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
Kamolchanok NgamkhamDepartment of Chemistry, University College London, London WC1H 0AJ, UK; The MRC/UCL Centre for Medical Molecular Virology, University College London, London WC1H 0AJ, UK.
Gwendolen C ReillyDepartment of Materials Science and Engineering, Insigneo Institute for in silico Medicine, The University of Sheffield, Sheffield S1 3JD, UK.
Adam J EnglerSanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA; Material Science Program, University of California, San Diego, La Jolla, CA 92093, USA; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: aengler@ucsd.edu.
Giuseppe BattagliaDepartment of Chemistry, University College London, London WC1H 0AJ, UK; The MRC/UCL Centre for Medical Molecular Virology, University College London, London WC1H 0AJ, UK. Electronic address: g.battaglia@ucl.ac.uk.
Sanford Consortium for Regenerative Medicine · USUniversity of Sheffield · GBMRC Laboratory for Molecular Cell Biology · GBUniversity College London · GBUniversity of California, San Diego · US

Funding

"Smart" Materials to Engineer a More Complete Stem Cell NicheDP2OD006460 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ENGLER, ADAM J · 2009 to 2009
$2.3M
NIH HHS DP02OD006460NIH HHS DP2 OD006460
6 · The paper itself

Abstract

Polymerized high internal phase emulsion (polyHIPE) foams are extremely versatile materials for investigating cell-substrate interactions in vitro. Foam morphologies can be controlled by polymerization conditions to result in either open or closed pore structures with different levels of connectivity, consequently enabling the comparison between 2D and 3D matrices using the same substrate with identical surface chemistry conditions. Additionally, here we achieve the control of pore surface topology (i.e. how different ligands are clustered together) using amphiphilic block copolymers as emulsion stabilizers. We demonstrate that adhesion of human mesenchymal progenitor (hES-MP) cells cultured on polyHIPE foams is dependent on foam surface topology and chemistry but is independent of porosity and interconnectivity. We also demonstrate that the interconnectivity, architecture and surface topology of the foams has an effect on the osteogenic differentiation potential of hES-MP cells. Together these data demonstrate that the adhesive heterogeneity of a 3D scaffold could regulate not only mesenchymal stem cell attachment but also cell behavior in the absence of soluble growth factors.

Indexed as

Biocompatible MaterialsCell AdhesionCell DifferentiationCell LineCell ProliferationHumansMesenchymal Stem CellsOsteogenesisPolymersPorosityTissue ScaffoldsBiocompatible MaterialsPolymersCell signalingOsteogenesisStem cellSurface topology

Identifiers

PMID25818420
PMCPMC4379418
OpenAlexW2028231009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.